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SCP0038

Sigma-Aldrich

Amyloid β 1-42 rat

≥90% (HPLC)

Synonym(s):

β-Amyloid 1-42, Amyloid for Rat, Rat Amyloid β 1-42

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500 μG
€366.00
1 MG
€576.00

€366.00

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500 μG
€366.00
1 MG
€576.00

About This Item

Empirical Formula (Hill Notation):
C199H307N53O59S1
Molecular Weight:
4417.95
UNSPSC Code:
12352200
NACRES:
NA.32

€366.00

Please contact Customer Service for Availability
Request a Bulk Order

Assay

≥90% (HPLC)

form

lyophilized

composition

Peptide Content, ≥75%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

General description

Amyloid β (Aβ) 1-42 is the major Aβ species in the amyloid plaques that develop in the case of Alzheimer′s disease (AD). It has a cross-β structure with parallel, in-register β-sheets.

Application

Amyloid β 1-42 rat has been used as an amyloid β (Aβ) oligomer in intracerebroventricular (ICV) injection/intra-hippocampal infusion to establish the Alzheimer′s disease (AD) model in rat.

Biochem/physiol Actions

Amyloid β 1-42 forms amyloid fibrils more readily compared to Aβ(1–40), in vitro. Aβ1-42 injections are known to cause brain dysfunction indicating learning and memory deficits. Amyloid β (Aβ) refers to peptides derived from amyloid precursor protein that vary in length from 37–43 amino acids. Aβ(s) peptides, their peptide fragments, and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding, and mechanisms of protein cross-linking in the context of diseases such as Alzheimer′s disease and neurodegeneration.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
E1375
E1327
E1271
E1246
E1221

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Jing Wang et al.
Molecular medicine reports, 23(6) (2021-04-22)
Ginkgolide B (GB), the diterpenoid lactone compound isolated from the extracts of Ginkgo biloba leaves, significantly improves cognitive impairment, but its potential pharmacological effect on astrocytes induced by β‑amyloid (Aβ)1‑42 remains to be elucidated. The present study aimed to investigate the
Enes Akyuz et al.
Biomedicines, 8(3) (2020-03-19)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex etiology and characterized by cognitive deficits and memory loss. The pathogenesis of AD is not yet completely elucidated, and no curative treatment is currently available. Inwardly rectifying potassium (Kir)
Volodymyr A Yavorsky et al.
Frontiers in cellular neuroscience, 17, 1132092-1132092 (2023-05-01)
One of the signs of Alzheimer's disease (AD) is the formation of β-amyloid plaques, which ultimately lead to the dysfunction of neurons with subsequent neurodegeneration. Although extensive researches have been conducted on the effects of different amyloid conformations such as
Raheleh Farahzadi et al.
ACS chemical neuroscience, 11(10), 1424-1435 (2020-04-21)
Mesenchymal stem cells (MSCs) are of particular interest because of their potential in regenerative medicine. Stem cell-based therapies cast a new hope for neurodegenerative disease treatment as a regeneration strategy, including treatment for Alzheimer's disease (AD). A multitude of cytokines
Ruo-Meng Li et al.
Neural regeneration research, 18(6), 1347-1353 (2022-12-02)
Previous studies have shown that fibroblast growth factor 13 is downregulated in the brain of both Alzheimer's disease mouse models and patients, and that it plays a vital role in the learning and memory. However, the underlying mechanisms of fibroblast
View All Related Papers

Questions

  1. What's the preparation instruction and how long is the incubation period?

    1 answer

    1. This product has not been tested for solubility or in vitro use. However there are publications available that may be helpful. Please see the information and links to the articles below:

      Aβ1-42 was dissolved in sterile water at a concentration of 2 mmol/L and incubated at 37 °C for 24 h.
      https://www.nature.com/articles/aps2013203

      A solution of 200 ng/μL concentration of Aβ was prepared in PBS (0.1 M). The solution of Aβ was incubated for 5 days at 37⁰C, and before injection, PBS was added to the solution to reach a final concentration of 10 ng/μL.
      https://www.researchgate.net/publication/346096849_Original_Article_Improvement_of_Learning_and_Memory_Deficits_With_Aerobic_Training_and_Donepezil_Co-therapy_in_Amyloid-b_beta-injected_Male_Rats_Through_the_CREB_and_BDNF_Signaling_Pathway

      Helpful?

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