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Key Documents

SAB4501661

Sigma-Aldrich

Anti-RHOA antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ARH12, ARHA, ARHA2, H12, RHO12

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100 μG
€391.00

€391.00

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100 μG
€391.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

€391.00

Please contact Customer Service for Availability

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 21 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P61586

UniProt accession no.

P61586

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RHOA(387)

General description

Anti-RHOA Antibody detects endogenous levels of total RHOA protein.
RhoA (ras homolog family member A) belongs to the Rho GTPase family of proteins. It is located on human chromosome 3p21.31.

Immunogen

The antiserum was produced against synthesized peptide derived from human RhoA.

Immunogen Range: 144-193

Biochem/physiol Actions

In multiciliated epithelial cells, RhoA (ras homolog family member A) controls the actin network dynamics. It also modulates membrane protrusion and contractility in the cell body. RhoA is one of the essential factor for Ras transformation. It is associated with cancer metastasis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
210568

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GPX1 (Glutathione Peroxidase 1)
Kulak MV and Weigel RJ
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2014)
Spatiotemporal dynamics of RhoA activity in migrating cells
Pertz O, et al.
Nature, 440(7087), 1069-1072 (2006)
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation
Khosravi-Far R, et al.
Molecular and Cellular Biology, 15(11), 6443-6453 (1995)
RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells
Sedzinski J, et al.
Journal of Cell Science, 130(2), 420-428 (2017)
Variegated RHOA mutations in human cancers
Kataoka K and Ogawa S
Experimental Hematology, 44(12), 1123-1129 (2016)
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