SAB4500043

Anti-G3BP-1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): ATP-dependent DNA helicase VIII, G3BP-1, GAP SH3 domain-binding protein 1, HDH-VIII, Ras GTPase-activating protein-binding protein 1
• MDL number: MFCD02262927
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 52 kDa
• species reactivity: mouse, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: Q13283
• UniProt accession no.: Q13283
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... G3BP1(10146)

Description

General description

Anti-G3BP-1 Antibody detects endogenous levels of total G3BP-1 protein.

G3BP1 (ras-GTPase-activating protein SH3 domain-binding protein 1) is a constituent of SGs (stress granules). It is located on human chromosome 5q14.2-5q33.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human G3BP-1.

Immunogen Range: 199-248

Biochem/physiol Actions

G3BP1 (ras-GTPase-activating protein SH3 domain-binding protein 1) blocks the replication of HIV-1 (human immunodeficiency virus) in macrophages and T-cells. In gastric cancer patients, overexpression of G3BP1 leads to imperfect clinical predictions. It is required for the interactions of SG–PB (stress granule-processing bodies).

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable