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SAB1407028

Sigma-Aldrich

Anti-ARID3B antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

Synonym(s):

BDP, DRIL2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~27.8 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: suitable
western blot: 1 μg/mL

NCBI accession no.

BC060824

UniProt accession no.

Q8IVW6

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ARID3B(10620)

General description

AT-rich interaction domain 3B (ARID3B) is encoded by the gene mapped to human chromosome 15q24.1. It is mainly expressed in leukocytes, placenta and testis. ARID3B belongs to the AT-rich interaction domain (ARID) family of proteins.
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. (provided by RefSeq)

Immunogen

ARID3B (AAH60824.1, 1 a.a. ~ 253 a.a) full-length human protein.

Sequence
MEPLQQQQQQQQQQQKQPHLAPLQMDAREKQGQQMREAQFLYAQKLVTQPTLLSATAGRPSGSTPLGPLARVPPTAAVAQVFERGNMNSEPEEEDGGLEDEDGDDEVAEVAEKETQAASKYFHVQKVARQDPRVAPMSNLLPAPGLPPHGQQAKEDHTKDASKASPSVSTAGQPNWNLDEQLKQNGGLAWSDDADGGRGREISRDFAKLYELDGDPERKEFLDDLFVFMQKRGECASTHHSNSGNTDRVPTVC

Biochem/physiol Actions

AT-rich interaction domain 3B (ARID3B) plays a vital role in the survival of neural crest during embryogenesis. It is involved in the pathogenesis of malignant neuroblastoma. ARID3B also facilitates the expression of pro-apoptotic p53-target genes and apoptosis.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Genetics of Blood Pressure and Hypertension: The Role of Rare Variation
Doris P A, et al.
Cardiovascular Therapeutics, 29(1), 37-45 (2011)
ARID3B Induces Malignant Transformation of Mouse Embryonic Fibroblasts and Is Strongly Associated with Malignant Neuroblastoma
Kobayashi K, et al.
Cancer Research, 66(17), 8331-8336 (2006)
Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis.
Pratama E, et al.
Biochemical and Biophysical Research Communications, 468(1-2), 248-254 (2015)
An additional case of the recurrent 15q24. 1 microdeletion syndrome and review of the literature.
Ng I S, et al.
Twin Research and Human Genetics : The Official Journal of the International Society for Twin Studies, 14(4), 333-339 (2011)

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