MUSTN1 gene was initially discovered in fracture callus tissue. The gene codes for a small nuclear protein and is known to be widely expressed in skeletal muscle. MUSTN1 expression is observed during embryogenesis in the developing muscles and somites. Its maximum expression is observed from the third month of life. The gene is highly conserved among the vertebrates. The gene is known to contain a nuclear localization sequence, phosphorylation and myristoylation sites.
Musculoskeletal, embryonic nuclear protein 1 (MUSTN1) is encoded by the gene is mapped to human chromosome 3p21.1.
Immunogen
synthetic peptide corresponding to amino acids 6-20of human MUSTN1
Biochem/physiol Actions
MUSTN1 is involved in bone development and regeneration, as well as chondrogenesis. It is critical in the regulation of myogenic differentiation and myofusion as its knock-down inhibits the processes.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Mustn1 encodes a small nuclear protein expressed specifically in the musculoskeletal system that was originally identified as a strongly up-regulated gene during bone regeneration, especially in fracture callus proliferating chondrocytes. Further experiments were undertaken to investigate its expression and role
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to chromosome 3p21 reveals cis-acting eQTLs at GNL3 and SPCS1
American journal of physiology. Cell physiology, 298(5), C1100-C1108 (2010-02-05)
Mustn1 (Mustang, musculoskeletal temporally activated novel gene) was originally identified in fracture callus tissue, but its greatest expression is detected in skeletal muscle. Thus, we conducted experiments to investigate the expression and function of Mustn1 during myogenesis. Temporally, quantitative real-time
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