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P7842

Sigma-Aldrich

Prepro-Thyrotropin Releasing Hormone Fragment 178-199

Synonym(s):

CRIF, Corticotropin release inhibiting factor

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About This Item

Empirical Formula (Hill Notation):
C116H176N28O39S
CAS Number:
122018-92-2
Molecular Weight:
2618.87
MDL number:
MFCD00080148
UNSPSC Code:
12352200

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCC(O)=O)C(O)=O

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
101K1995
057H1217
021K1403
021K14031

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E Redei et al.
Neuroreport, 10(16), 3273-3276 (1999-12-22)
This study examined the central effects of rat prepro-TRH 178-199, a peptide with corticotropin release inhibiting activity at the pituitary, on the Porsolt forced swim test (FST) of depressive behavior in rats. Subacute intracerebroventricular administration of prepro-TRH 178-199 dose-responsively reduced
K Valentijn et al.
Neuroscience, 44(1), 223-233 (1991-01-01)
Thyrotropin-releasing hormone prohormone contains five copies of the thyrotropin-releasing hormone progenitor sequence Gln-His-Pro-Gly, each flanked by pairs of basic amino acids and separated by intervening sequences (connecting peptides). Using a perifusion system for rat hypothalamic slices, we have studied the
M Bulant et al.
The Journal of biological chemistry, 263(32), 17189-17196 (1988-11-15)
Rat thyrotropin-releasing hormone prohormone (pro-TRH) contains five separate copies of the TRH progenitor sequence: Gln-His-Pro-Gly. Each of the five sequences is flanked by pairs of basic residues and linked together by one of several predicted connecting sequences. Two of the
F Pecori Giraldi et al.
Journal of neuroendocrinology, 22(4), 294-300 (2010-02-09)
Prepro-thyrotrophin-releasing hormone (TRH) (178-199), a 22-amino acid cleavage product of the TRH prohormone, has been postulated to act as an adrenocorticotrophin hormone (ACTH)-release inhibitor. Indeed, although in vitro evidence indicates that this peptide may inhibit basal and stimulated ACTH secretion
T Mitsuma et al.
Endocrine regulations, 27(2), 49-55 (1993-06-01)
The effect of dexamethasone administration on the concentration of thyrotropin releasing hormone (TRH) and pre-pro-TRH connecting peptides TRH-glycine (TRH-Gly), and pre-pro-TRH (178-199) in various rat organs was studied. Three groups of 35 rats each were injected dexamethasone (Group A: 25
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