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P7762

Sigma-Aldrich

Poly-L-arginine hydrochloride

mol wt 15,000-70,000

Synonym(s):

L-Arginine homopolymer hydrochloride

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About This Item

CAS Number:
26982-20-7
MDL number:
MFCD00166393
UNSPSC Code:
12352209
PubChem Substance ID:
24898874
NACRES:
NA.26

form

powder

mol wt

15,000-70,000

color

white to off-white

application(s)

cell analysis

storage temp.

−20°C

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

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General description

Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.

Application

Poly-L-arginine hydrochloride has been used:
  • to generate complex with stimulatory RNA isRNA9.2 as in neutrophils
  • used in ribosomal RNA transfection into human monocytic THP-1 cells
  • for coating alginate capsule beads

Quality

Contains 3% or less ornithine residue.

Analysis Note

Molecular weight based on viscosity of precursor poly-L-ornithine. Also assayed by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Neutrophils express distinct RNA receptors in a non-canonical way
Berger M, et al.
The Journal of Biological Chemistry, 287(23), 19409-19417 (2012)
Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells
Bhujbal SV, et al.
Journal of the Mechanical Behavior of Biomedical Materials, 37, 196-208 (2014)
Vaccination with poly-L-arginine as immunostimulant for peptide vaccines: induction of potent and long-lasting T-cell responses against cancer antigens
Mattner F, et al.
Cancer Research, 62(5), 1477-1480 (2002)
RNA of Enterococcus faecalis strain EC-12 is a major component inducing interleukin-12 production from human monocytic cells
Nishibayashi R, et al.
PLoS ONE, 10(6), e0129806-e0129806 (2015)
M Miyamoto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 21-30 (2001-07-05)
The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9
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