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Key Documents

P1038

Sigma-Aldrich

Poly(cytidylic-inosinic) acid potassium salt

random copolymer

Synonym(s):

Poly (C,I)

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About This Item

CAS Number:
26301-44-0
MDL number:
MFCD00167396
UNSPSC Code:
41106305
NACRES:
NA.51

Quality Level

200

form

powder

storage temp.

−20°C

Application

Poly(cytidylic-inosinic) acid potassium salt has been used:
  • in pretreatment to understand Con A-induced hepatitis in mice[1]
  • in RNA extraction from hemolymph plasma for qPCR detection assay[2]
  • to induce inflammatory changes in liver[3]
  • as a component of minimal essential medium for the stimulation of rainbow trout gonad line RTG-2 cells[4]

Biochem/physiol Actions

Poly(cytidylic-inosinic) Poly(C,I) is a random copolymer of inosine and cytidine bases which may be useful for comparative physicochemical analysis versus other random copolymers such as Poly(C,A), Poly(C,U) and Poly(C,G).
Poly(cytidylic-inosinic) acid, poly I:C mimics viral RNA to induce immune response. Administration of poly I:C promotes cytotoxic functionality of natural killer cells and macrophages. However, poly I:C may trigger generation of anti-mitochondrial antibodies (AMAs) and contribute to the pathogenesis of primary biliary cirrhosis (PBC).[3] Poly I:C may play a hepatoprotective role in Con A-induced T cell-dependent liver injury.[1]

Other Notes

Random copolymer

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
063M4020V
086M4060V
12120609
093M4020V
022M4048V

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G F Joyce et al.
Journal of molecular biology, 176(2), 279-306 (1984-06-25)
Poly(C, U) random copolymer templates direct the oligomerization of 2-MeImpG and 2-MeImpA, resulting in the production of a variety of oligo/(G,A)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpA, and decreases for
G F Joyce et al.
Journal of molecular biology, 202(3), 677-681 (1988-08-05)
Poly(C,A) random copolymer templates direct the oligomerization of 2-MeImpG (2-MeImpX is the 5'-phospho-2-methylimidazolide of the nucleoside X) and 2-MeImpU, resulting in the production of a variety of oligo (G,U)s. This reaction is less efficient than comparable reactions involving poly(C,U) or
G F Joyce et al.
Journal of molecular biology, 188(3), 433-441 (1986-04-05)
Poly(C, G) random copolymer templates direct the oligomerization of 2-Me-ImpG and 2-MeImpC, resulting in the production of a variety of oligo(G, C)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpC, and decreases
Persistence of double-stranded RNA in insect hemolymph as a potential determiner of RNA interference success: evidence from Manduca sexta and Blattella germanica
Garbutt JS, et al.
Journal of Insect Physiology, 59(2), 171-178 (2013)
The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I: C) and murine autoimmune cholangitis
Wang J, et al.
Journal of Hepatology, 44(3), 446-454 (2006)
View All Related Papers

Questions

1–5 of 5 Questions  

  1. Will Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, work to induce interferon production?

    1 answer

    1. P1038 is a single stranded RNA. For cell activation, synthetic double-stranded RNA is widely used as the ligand of Toll-like receptor 3 (TLR3) in place of what is supposed to be the natural ligand (viral dsRNA). This would be Product No. P9582, a double stranded RNA homopolymer, i.e. Poly(I): Poly(C). This product is widely used by other satisfied customers for cell activation.

      Helpful?

  2. Is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, product sterile?

    1 answer

    1. Product No. P1038 is not sterile. The product is produced in non-sterile conditions and the level of endotoxin content is not determined.

      Helpful?

  3. What can I use to solubilize Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?

    1 answer

    1. The product is soluble in water at 10 mg/mL.

      Helpful?

  4. How large/long a polymer is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?

    1 answer

    1. The average length of this polynucleotide has not been determined.

      Helpful?

  5. Is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, single or double stranded?

    1 answer

    1. Product No. P1038 is a single-stranded random co-polymer.

      Helpful?

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