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N3135

Supelco

Nalorphine hydrochloride

Synonym(s):

N-Allylnormorphine HCl, Nalline HCl

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About This Item

Empirical Formula (Hill Notation):
C19H21NO3 · HCl
CAS Number:
57-29-4
Molecular Weight:
347.84
EC Number:
200-321-8
MDL number:
MFCD00055164
UNSPSC Code:
41116107
Pricing and availability is not currently available.

drug control

USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

H2O: slightly soluble
dilute aqueous acid: soluble
ethanol: soluble

SMILES string

Cl[H].O[C@H]1C=CC2[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45

InChI

1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12?,13-,15+,18+,19+;/m1./s1

InChI key

NAHATSPWSULUAA-HWXFZQNOSA-N

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Biochem/physiol Actions

Antagonist at μ receptors, partial agonist at κ receptors, and agonist at sigma receptors, but does not have high affinity for the sigma receptor

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
099H3358
124F0744
103H3384
088F0121
034H3369

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C Y Cheng et al.
Bioorganic & medicinal chemistry, 4(1), 73-80 (1996-01-01)
N-Cubylmethylnormorphine (1) and N-cubylmethylnoroxymorphone (2) have been synthesized and found to be more potent ligands at the mu and kappa opioid receptors than morphine and oxymorphone respectively. In the guinea-pig ileum preparation, compounds 1 and 2 were characterized as opioid
R Xie et al.
Pharmaceutical research, 15(4), 570-575 (1998-05-20)
The purpose of the study was to investigate the distribution of codeine across the blood-brain barrier (BBB) in rats by microdialysis (MD). Rats were administered intravenous infusion of codeine in doses of (1) 10 mg/kg, (2) 20 mg/kg for 10
M R Bouw et al.
Pharmaceutical research, 15(11), 1673-1679 (1998-12-02)
To investigate the performance of two alternative retrodialysis recovery methods and to describe the influence of different recoveries on the reliability in estimating unbound extracellular concentrations of morphine. Unbound concentrations of morphine in striatum and in blood were determined by
D M Sherman et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (2)(2), 11-14 (2004-06-24)
Acute experiments on 75 adult rabbits were made to study action of intravenous injections of naloxone (0.1 mg/kg), nalorphine (0.5 and 2.0 mg/kg) and dalargin (0.1 mg/kg) in early and late periods of irreversible shock caused by combination of non-shockogenic
Cătălina Lionte et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 111(1), 111-114 (2007-06-29)
Respiratory arrest is a major emergency in medical practice, which implies prompt intervention from the physician assisting such case. Respiratory arrest can be classified into primary respiratory arrest, caused by airway obstruction, decreased respiratory drive, or respiratory muscle weakness and
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