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M0880

Sigma-Aldrich

Ethyl methanesulfonate

liquid

Synonym(s):

Ethyl mesylate, Methanesulfonic acid ethyl ester

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About This Item

Linear Formula:
CH3SO3CH2CH3
CAS Number:
62-50-0
Molecular Weight:
124.16
Beilstein:
773969
EC Number:
200-536-7
MDL number:
MFCD00007559
UNSPSC Code:
12352108
PubChem Substance ID:
24896575
NACRES:
NA.25

form

liquid

refractive index

n20/D 1.418 (lit.)

bp

85-86 °C/10 mmHg (lit.)

density

1.206 g/mL at 20 °C

SMILES string

CCOS(C)(=O)=O

InChI

1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3

InChI key

PLUBXMRUUVWRLT-UHFFFAOYSA-N

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Application

Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.

Biochem/physiol Actions

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

212.0 °F

Flash Point(C)

100 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency
Birnbaum MD, et al.
Cell Chemical Biology (2018)
Yu-Long Gao et al.
Journal of integrative plant biology, 62(2), 165-180 (2019-01-31)
Targeting-induced local lesions in genomes (TILLING) is a powerful reverse-genetics tool that enables high-throughput screening of genomic variations in plants. Although TILLING has been developed for many diploid plants, the technology has been used in very few polyploid species due
The effects of thymol on sister chromatid exchange, chromosome aberration and micronucleus in human lymphocytes
Buyukleyla M and Rencuzogullari E
Ecotoxicology and Environmental Safety, 72(3), 943-947 (2009)
Kamel El Omari et al.
Nature communications, 10(1), 846-846 (2019-02-21)
Lipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in prokaryotes. Haloarchaeal pleomorphic
Establishment of a human somatic hybrid cell line for recombinant protein production
Cho MS, et al.
Journal of Biomedical Science, 9(6), 631-638 (2002)
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