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L8170

Sigma-Aldrich

Pseudolaric Acid B

≥98% (HPLC)

Synonym(s):

(-)-Pseudolaric acid B, O-Acetylpseudolaric acid C, Pseudolarix acid B

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About This Item

Empirical Formula (Hill Notation):
C23H28O8
CAS Number:
82508-31-4
Molecular Weight:
432.46
MDL number:
MFCD26960905
UNSPSC Code:
12352106
NACRES:
NA.25

biological source

Larix kaempferi

Assay

≥98% (HPLC)

form

powder or crystals

storage condition

protect from light

color

white to off-white

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

O=C(OC)C1=CC[C@@]2(C(O[C@@](/C=C/C=C(C(O)=O)\C)(C)[C@@H]3CC2)=O)[C@]3(OC(C)=O)CC1

InChI

1S/C23H28O8/c1-14(17(24)25)6-5-10-21(2)16-9-12-22(19(27)31-21)11-7-15(18(26)29-3)8-13-23(16,22)20(28)30-4/h5-7,10,16H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,14-6+/t16-,21+,22+,23+/m0/s1

InChI key

XRLYZNSOXNPKOR-CBDALDGHSA-N

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Biochem/physiol Actions

Pseudolaric acid B, a natural diterpenoid compound, is isolated from Pseudolarix kaempferi. It has shown antifungal, antifertility, and antiangiogenic properties. It also may exihibit anti-cancer and anti-inflammatory properties.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H361fd

Precautionary Statements

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Taradas Sarkar et al.
Biochemical pharmacology, 84(4), 444-450 (2012-05-29)
We purified pseudolaric acid B (PAB) from the root and stem bark of Pseudolarix kaempferi (Lindl.) Gorden. Confirming previous findings, we found that the compound had high nanomolar IC₅₀ antiproliferative effects in several cultured cell lines, causing mitotic arrest and
Min Qi et al.
Journal of pharmacological sciences, 121(3), 200-211 (2013-02-27)
Pseudolaric acid B (PAB) is the primary biologically active compound isolated from the root bark of P. kaempferi Gordon. Our previous study demonstrated that PAB induced mitotic catastrophe in L929 cells and indicated that only a small percentage (12%) of
Ai-guo Meng et al.
Acta pharmacologica Sinica, 30(4), 442-450 (2009-03-24)
The aim of this study was to investigate the mechanism of pseudolaric acid B (PLAB)-induced cell cycle arrest in human melanoma SK-28 cells. Cell growth inhibition was detected by MTT assay, the cell cycle was analyzed by flow cytometry, and
Pauline Chiu et al.
Natural product reports, 27(7), 1066-1083 (2010-04-21)
The pseudolaric acids are diterpenoids isolated from the root bark of Pseudolarix amabilis, or the golden larch. Pseudolaric acids A and B are the major antifungal and anti-angiogenic congeners of this family of compounds. This review presents the results of
Peng Liu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 46(11), 1361-1365 (2012-01-21)
The metabolic profile of pseudolaric acid B (PB) was investigated by using in vivo and in vitro tests. Pseudolaric acid C2 (PC2) was identified as the specific metabolite of PB in plasma, urine, bile and feces using HPLC and HPLC-ESI/MS(n)
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