K0515

Anti-Potassium Channel K_v12.1 (Elk1) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-KCNH8, Anti-Voltage gated K⁺ channel subfamily H member 8, Anti-ether-a-go-go like K⁺ channel 3
• UNSPSC Code: 12352203
• NACRES: NA.41
• conjugate: unconjugated
• application: WB
• clone: polyclonal
• species reactivity: rat
• citations: 3
• technique(s): western blot: 1:200 using rat cortex lysates

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: rat
• technique(s): western blot: 1:200 using rat cortex lysates
• UniProt accession no.: Q9QWS8
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: rat ... Kcnh8(246325)

Description

General description

The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8), also referred to as Elk1/Ets-1, belongs to the Ets family of transcription factors. The members of this subfamily are part of the ether-a-go-go (EAG) family of potassium channel pore-forming subunits. The rat elk mRNA is found to be expressed in brain. The rat elk subunits contain six hydrophobic membrane-spanning segments S1-S6, a P-domain, and a motif homologous to cyclic nucleotide-binding domains at the C-terminus.

Immunogen

peptide EDKKEDRAKGRSRAG(C) corresponding to amino acid residues 143-157 of rat K_V12.1.

Biochem/physiol Actions

The gene Kcnh8 (potassium voltage-gated channel subfamily H member 8) encodes a potassium channel pore-forming subunit that activates p21WAF1/Cip1 via cis-acting elements in p21WAF1/Cip1 and inhibits apoptosis of vascular smooth muscle cells. The potassium channel is found to mediate slowly activating sustained potassium currents.

Target description

K_v12.1 channel is confined mainly to the central nervous system with some expression in peripheral organs such as testis, colon and lung. The physiological function of the K_v12.1 channel hasn′t been established, although a role in the modulation of overall excitability of neurons has been suggested.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

Reconstitution

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H312,H412
• Precautionary Statements: P280
• Hazard Classifications: Acute Tox. 4 Dermal - Aquatic Chronic 3
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable