D044
Amfonelic acid
powder
Synonym(s):
7-Benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C18H16N2O3
CAS Number:
Molecular Weight:
308.33
MDL number:
UNSPSC Code:
12352200
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form
powder
color
yellow
solubility
0.1 M NaOH: soluble
H2O: slightly soluble
ethanol: soluble
Gene Information
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
Biochem/physiol Actions
Blocks dopamine uptake
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R W Fuller et al.
Research communications in chemical pathology and pharmacology, 48(1), 17-25 (1985-04-01)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) given in 4 daily s.c. injections to mice resulted in marked depletion of striatal dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) 1 week after the last dose. Pretreatment of mice with alpha-methyltyrosine or Ro 4-1284 to deplete
C Pu et al.
Brain research, 649(1-2), 217-224 (1994-06-27)
Administration of methamphetamine (MA) induces degeneration of dopaminergic nerve terminals and astrogliosis, such as hypertrophy and an increase in apparent number, in the neostriatum. In this experiment adult rats were treated with MA (10 mg/kg, i.p.) 4 times in one
A G Ewing et al.
Science (New York, N.Y.), 221(4606), 169-171 (1983-07-08)
Microvoltammetric electrodes were used to monitor dopamine released in the caudate nucleus of the rat after electrical stimulation of the medial forebrain bundle. The time resolution of the technique is sufficient to determine in vivo concentration changes on a time
A V Juorio
British journal of pharmacology, 77(3), 511-515 (1982-11-01)
1 The concentrations of p- and m-tyramine, dopamine and homovanillic acid were measured in the mouse striatum following the subcutaneous administration of amfonelic acid, (+)-amphetamine or nomifensine.2 The administration of 2.5-25 mg/kg of amfonelic acid produced a reduction in p-tyramine
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