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C8284

Sigma-Aldrich

Anti-C-Reactive Protein antibody produced in goat

whole antiserum

Synonym(s):

Anti-CRP

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

human

technique(s)

Ouchterlony double diffusion: 1:16-1:32

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CRP(1401)

General description

C-reactive protein (CRP) is a first acute-phase plasma protein. It is synthesized in the hepatocyte and the concentration increase during inflammatory states even chronic inflammation. It′s level can increase during inflammation by up to 100 or 500 times.
C-reactive protein is encoded by the gene mapped to human chromosome 1q23.2.

Specificity

Specificity for human CRP is determined by immunoelectrophoresis (IEP) versus human CRP positive serum and purified human CRP. No reactivity with normal human serum is observed.

Application

Anti-C-Reactive Protein antibody produced in goat has been used in enzyme-linked immunosorbent assay (ELISA). It has also been used in immunoassay reproducibility and binding affinity investigation of CRP-anti-CRP interaction.
Anti-C-Reactive protein antibody has been used in:
  • immunoassay reproducibility and binding affinity investigation of CRP-anti-CRP interaction.
  • in-house ELISA assay to study the CRP levels in plasma sample.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Enzyme-linked immunosorbent assay (1 paper)

Biochem/physiol Actions

C-reactive protein (CRP) plays an important role to provide an enhanced clearance of inappropriate materials from the plasma, whether these are of extrinsic origin, such as microorganisms and their products or the autologous products of cell damage and death. It acts as a systemic biomarker of acute inflammation and tissue damage.

Physical form

Goat Anti-Human CRP is supplied as a liquid containing 0.1% sodium azide (see MSDS) as preservative.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Intestinal parasites coinfection does not alter plasma cytokines profile elicited in acute malaria in subjects from endemic area of Brazil
Sanchez-AJC, et al.
Mediators of Inflammation (2014)
Chih-Shen Chuang et al.
Scientific reports, 9(1), 17131-17131 (2019-11-22)
In this study, we developed a portable smartphone-based diffusometry for analyzing the C-reactive protein (CRP) concentration. An optimized fluorescence microscopic add-on system for a smartphone was used to image the 300 nm fluorescent beads. Sequential nanobead images were recorded for a
C-reactive protein: a critical update.
Mark B Pepys et al.
The Journal of clinical investigation, 111(12), 1805-1812 (2003-06-19)
Andrew I Russell et al.
Human molecular genetics, 13(1), 137-147 (2003-12-03)
Relative deficiency of pentraxin proteins is implicated in the pathogenesis of systemic lupus erythematosus. The C-reactive protein (CRP) response is defective in patients with acute flares of disease, and mice with targeted deletions of the serum amyloid P component gene
M B Pepys et al.
Advances in immunology, 34, 141-212 (1983-01-01)
The acute phase response among plasma proteins is a normal response to tissue injury and is therefore a fundamental aspect of many diverse disease processes. It probably usually has a beneficial net function in limiting damage and promoting repair but

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