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C7518

Sigma-Aldrich

L-Carnitine hydrochloride

≥97%, from equine muscle

Synonym(s):

(−)-β-Hydroxy-γ-(trimethylammonio)butyrate, Vitamin BT

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About This Item

Linear Formula:
(CH3)3N+CH2CH(OH)CH2CO2H · Cl-
CAS Number:
6645-46-1
Molecular Weight:
197.66
EC Number:
229-663-6
MDL number:
MFCD00066100
UNSPSC Code:
12352200
PubChem Substance ID:
24892966

biological source

equine muscle

Assay

≥97%

storage temp.

−20°C

SMILES string

[Cl-].C[N+](C)(C)C[C@H](O)CC(O)=O

InChI

1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m1./s1

InChI key

JXXCENBLGFBQJM-FYZOBXCZSA-N

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Biochem/physiol Actions

Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Johana Vásquez-Procopio et al.
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Silvana Constantinescu et al.
Canadian journal of physiology and pharmacology, 93(11), 913-922 (2015-09-26)
We have shown that reduced expression of receptor-interacting protein 140 (RIP140) alters the regulation of fatty-acid (FA) oxidation in muscle. To determine whether a high level of FA availability alters the effects of RIP140 on metabolic regulation, L6 myotubes were
Aris A Polyzos et al.
Cell metabolism, 29(6), 1258-1273 (2019-04-02)
The basis for region-specific neuronal toxicity in Huntington disease is unknown. Here, we show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes. Glucose is low in HdhQ(150/150) animals, and astrocytes in each brain region adapt by metabolically reprogramming
Vladimir V Dynnik et al.
PloS one, 10(7), e0134145-e0134145 (2015-07-29)
The aim of present study was to investigate the effects of ammonium ions on in vitro neuronal network activity and to search alternative methods of acute ammonia neurotoxicity prevention. Rat hippocampal neuronal and astrocytes co-cultures in vitro, fluorescent microscopy and

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