C5493

CyPPA

≥98% (HPLC), solid

• Synonym(s): Cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine
• Empirical Formula (Hill Notation): C₁₆H₂₃N₅
• CAS Number: 73029-73-9
• Molecular Weight: 285.39
• MDL number: MFCD01550586
• UNSPSC Code: 12352200
• PubChem Substance ID: 329775087
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1cc(NC2CCCCC2)nc(n1)-n3nc(C)cc3C
• InChI: 1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)
• InChI key: USEMRPYUFJNFQN-UHFFFAOYSA-N

Description

Application

CyPPA has been used:

• to test its inhibitory functionality on melanogenesis
• as an activator of small conductance potassium channel-3 (SK3) in mesenteric artery segments
• in the activation of calcium-activated potassium (SK) channels in murine hippocampal neurons HT-22 cells

Biochem/physiol Actions

CyPPA is a positive modulator of small conductance Ca²⁺-activated K⁺ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC₅₀ of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335,H413
• Precautionary Statements: P273 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves