C1997

CYM-5442

≥98% (HPLC)

• Synonym(s): 2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol
• Empirical Formula (Hill Notation): C₂₃H₂₇N₃O₄
• CAS Number: 1094042-01-9
• Molecular Weight: 409.48
• MDL number: MFCD12912402
• UNSPSC Code: 12352211
• PubChem Substance ID: 329774920
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: >5 mg/mL
• storage temp.: −20°C
• SMILES string: CCOc1ccc(cc1OCC)-c2nc(no2)-c3cccc4C(CCc34)NCCO
• InChI: 1S/C23H27N3O4/c1-3-28-20-11-8-15(14-21(20)29-4-2)23-25-22(26-30-23)18-7-5-6-17-16(18)9-10-19(17)24-12-13-27/h5-8,11,14,19,24,27H,3-4,9-10,12-13H2,1-2H3
• InChI key: NUIKTBLZSPQGCP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo through a hydrophobic pocket, separable from the orthosteric site of S1P binding that is headgroup dependent. This is a different site from those involved in the activities of other agonists such as FTY720 and SEW2871.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves