A2734

α5IA

≥98% (HPLC)

• Synonym(s): 1,2,4-Triazolo[3,4-a]phthalazine, 3-(5-methyl-3-isoxazolyl)-6-[(1-methyl-1H-1,2,3-triazol-4-yl)methoxy]-, 3-(5-Methylisoxazol-3-yl)-6-(1-methyl-1,2,3-triazol-4-yl)methoxy-1,2,4-triazolo[3,4-a]phthalazine
• Empirical Formula (Hill Notation): C₁₇H₁₄N₈O₂
• CAS Number: 215874-86-5
• Molecular Weight: 362.35
• MDL number: MFCD09832717
• UNSPSC Code: 12352200
• PubChem Substance ID: 329770794
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: off-white to light yellow
• solubility: DMSO: >2 mg/mL
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• storage temp.: 2-8°C
• SMILES string: Cc1cc(no1)-c2nnc3c4ccccc4c(OCc5cn(C)nn5)nn23
• InChI: 1S/C17H14N8O2/c1-10-7-14(22-27-10)16-20-19-15-12-5-3-4-6-13(12)17(21-25(15)16)26-9-11-8-24(2)23-18-11/h3-8H,9H2,1-2H3
• InChI key: NZMJFRXKGUCYNP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

α5IA is a selective inverse agonist for Α5 subtype of GABAA receptor with a higher intrinsic activity at the A5 subtype than other drugs. α5IA enhances cognition in laboratory animals without being proconvulsant or anxiogenic. α5IA acts as an "alcohol antagonist," markedly reducing the amnesic effect of alcohol and partially attenuating sedation, similar to Ro15-4513, but without the anxiogenic effect. α5IA offers promise as a tool to study cognitive disorders, memory function, and treatment of alcohol-related disorders.

α5IA is a selective inverse agonist for a5 subtype of GABAA receptor.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves