A1471

A-85783

• Synonym(s): (R)-6-(4-Fluorophenyl)-N,N-dimethyl-3-[3-(3-pyridinyl)-1H,3H-pyrrolo[1,2-c]thiazol-7-yl]carbonyl-1H-indole-1-carboxamide
• Empirical Formula (Hill Notation): C₂₉H₂₃FN₄O₂S
• CAS Number: 161395-33-1
• Molecular Weight: 510.58
• MDL number: MFCD00935061
• UNSPSC Code: 12352200
• PubChem Substance ID: 329770708

Properties

• form: solid
• mp: 185.3-186.5 °C (lit.)
• solubility: DMSO: 13 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: CN(C)C(=O)n1cc(C(=O)c2ccn3[C@H](SCc23)c4cccnc4)c5ccc(cc15)-c6ccc(F)cc6
• InChI: 1S/C29H23FN4O2S/c1-32(2)29(36)34-16-24(22-10-7-19(14-25(22)34)18-5-8-21(30)9-6-18)27(35)23-11-13-33-26(23)17-37-28(33)20-4-3-12-31-15-20/h3-16,28H,17H2,1-2H3/t28-/m1/s1
• InChI key: YGUVFPOGHIKVPP-MUUNZHRXSA-N

Description

General description

Shown to be effective both in vivo and in vitro. A-85783 is neutral and lipophilic and has been shown to competitively and reversibly inhibit [³H]PAF binding to rabbit platelet membranes as well as block PAF-induced serotonin release from rabbit platelets.

Biochem/physiol Actions

Potent and selective platelet-activating factor (PAF) receptor antagonist.

Features and Benefits

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold under license from Abbott Laboratories.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves