This product is considered a pure material rather than a solution. The concentration can be determined by dividing the density by the molecular weight and correcting for units. This gives 6.37M, which would then need to be multiplied by the batch-specific density for the batch in question, as the material is not 100% pure.
85558
Spermidine
BioUltra, for molecular biology, ≥99.5% (GC)
Synonym(s):
SPD, 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane
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1 G
€59.10
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€206.00
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1 G
€59.10
5 G
€206.00
About This Item
Linear Formula:
NH2(CH2)3NH(CH2)4NH2
CAS Number:
Molecular Weight:
145.25
Beilstein:
1698591
EC Number:
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.26
Recommended Products
grade
for molecular biology
Quality Level
product line
BioUltra
Assay
≥99.5% (GC)
storage condition
(Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.)
technique(s)
ChIP: suitable
buffer exchange: suitable
impurities
DNases, none detected
RNases, none detected
insoluble matter, passes filter test
phosphatases, none detected
proteases, none detected
refractive index
n20/D 1.479 (lit.)
pH
12.0-13.5 (25 °C, 1 M in H2O)
solubility
H2O: 1 M at 20 °C, clear, colorless
density
0.925 g/mL at 25 °C (lit.)
anion traces
chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg
cation traces
Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg
λ
1 M in H2O
UV absorption
λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.05
SMILES string
NCCCCNCCCN
suitability
suitable for molecular biology
application(s)
advanced drug delivery
genomic analysis
InChI
1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChI key
ATHGHQPFGPMSJY-UHFFFAOYSA-N
Gene Information
rat ... Ppm1a(24666)
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General description
Spermidine is a polyamine[1] and a trivalent organic cation.[2]Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses.
Application
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine modulates various cellular activities like cellular growth and development, stability of DNA and apoptosis.[1]
Features and Benefits
- Versatile and adaptable for a wide variety of laboratory and research applications
- Suitable for Molecular Biology and Biochemical research
- Free from DNase, RNase, NICKase, and protease
- Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
- Tested for trace levels of Anions and Cations
Caution
Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.
Analysis Note
liquid or solid
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Flash Point(F)
233.6 °F - closed cup
Flash Point(C)
112 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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What's the molar concentration of the product? Is it 1M?
1 answer-
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What is the container for item 85558-1G Spermidine and 43816-10mL DL-Dithiothreitol solution?
1 answer-
Both items are from Buchs. Item 85558-1g comes in a narrow neck glass bottle, 5 ml, amber. Item 43816-10mL is a 15 ml plastic tube made of polypropylene (PP) and includes a sterile cap.
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Under which conditions should this UNopened product be stored? What is the shelf life of an UNopened product? Under which conditions should this OPENED product be stored? What is the shelf life of an OPENED product?
1 answer-
This product may be stored at room temperature. For products with no specified storage temperature given on the label or product page, ambient storage may be assumed. No change in storage temperature is required after opening provided that the item is handled properly and free of contaminants. This product is not assigned an expiration date. While considered stable, this item may be subject to degradation over time and is assigned a periodic retest date to confirm quality. The lot specific retest date is reported on the Certificate of Analysis. See the link below to review a sample of lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/85558#product-documentationHelpful?
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spermidine 85558. I have received 1 G in liquid. Can you please tell me 1G in what volume? and what solution? Never mentioned anywhere.
1 answer-
The product is a neat or pure compound with a melting point of approximately room temperature. The material may be received as either a liquid or a solid. The density of this product is 0.925 g/mL and the concentration is 6.4M.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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Is this a spermidine solution or a neat liquid, and what is the concentration?
1 answer-
Based on a density of 0.925 g/mL and a molecular weight of 145.25, this neat liquid has an effective molarity of 6.4 M.
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