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S1878

Sigma-Aldrich

Sodium (meta)periodate

≥99.0%

Synonym(s):

Sodium periodate

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100 G
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25 G
€50.10
100 G
€106.00
500 G
€344.00

About This Item

Linear Formula:
NaIO4
CAS Number:
7790-28-5
Molecular Weight:
213.89
EC Number:
232-197-6
MDL number:
MFCD00003534
UNSPSC Code:
12352302
PubChem Substance ID:
329824494
NACRES:
NA.55
Assay:
≥99.0%
form:
powder
solubility:
H2O: 50 mg/mL

€50.10

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Quality Level

300

Assay

≥99.0%

form

powder

reaction suitability

reagent type: oxidant

pH

3.5-5.5 (25 °C, 107 g/L)

solubility

H2O: 50 mg/mL

SMILES string

[Na+].[O-]I(=O)(=O)=O

InChI

1S/HIO4.Na/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1

InChI key

JQWHASGSAFIOCM-UHFFFAOYSA-M

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General description

Sodium (meta)periodate is commonly used as an oxidizing agent in organic synthesis for the oxidation of various organic substrates. It can also be used as a co-oxidant with other oxidizing reagents such as osmium tetroxide and potassium permanganate. The oxidation of sodium periodate takes place in a water medium, but an organic co-solvent is used for organic substrates that are insoluble in water.

Application

Sodium (meta)periodate can be used as an oxidizing agent for the oxidation of:      
  • 1,2-diols to aldehydes or ketones via oxidative cleavage.       Sulfides to sulfoxides in the presence of phase transfer catalysts.      
  • Diaryl, dialkyl, and aryl alkyl selenides to the respective selenoxides.      
  • Phenols and their derivatives to corresponding quinones.
  • Acylphosphoranes to α,β-dicarbonyl compounds.

It can also be used in the:      
  • Selective alkene epoxidation and alkane hydroxylation,·
  • Oxidation of carbohydrates.      
  • Iodination of aromatic compounds.

Useful reagent for the oxidation of carbohydrates prior to labeling with biotin hydrazide

Features and Benefits

NaIO4 is a stable, selective, and cost-effective reagent that is capable of reacting under mild conditions.

Signal Word

Danger

Hazard Statements

H271,H314,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1C - STOT RE 1

Target Organs

Thyroid

Storage Class Code

5.1A - Strongly oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT9477
MKCT2397
MKCS2972
MKCR9473
MKCR7722

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Dextrin, a glucose polymer with low molecular weight, was used to develop a fully resorbable hydrogel, without using chemical initiators. Dextrin was first oxidized (oDex) with sodium periodate and then cross-linked with adipic acid dihidrazide, a nontoxic cross-linking molecule. Furthermore
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Questions

1–6 of 6 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What can Sodium (meta)periodate, Product S1878, be used for?

    1 answer

    1. Sodium metaperiodate is used by synthetic chemists as an effective oxidant. It is a stable, specific, cost-effective reagent that is capable of reacting under mild conditions. It has been used to cleave vicinal diols to carbonyl compounds, convert sulfides into sulfoxides and oxidize primary and secondary halides to the corresponding aldehydes and ketones.

      Helpful?

  4. How long is Sodium (meta)periodate, Product S1878, good for?

    1 answer

    1. Sodium metaperiodate is extremely stable at room temperature. Sigma-Aldrich assigns a recommended retest period of 8 years to this product as seen on the product's specification sheet.

      Helpful?

  5. What is Sodium (meta)periodate, Product S1878, soluble in?

    1 answer

    1. We have tested the solubility of this compound in water at 100mg/mL; heat may be required to get it to dissolve at that concentration. Per the chemicals encyclopedia published by the Royal Society of Chemistry, it is also expected to be soluble in sulfuric, nitric and acetic acids.

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  6. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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