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I3132

Supelco

Indoprofen

analytical standard

Synonym(s):

α-Methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid

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About This Item

Empirical Formula (Hill Notation):
C17H15NO3
CAS Number:
31842-01-0
Molecular Weight:
281.31
EC Number:
250-833-0
MDL number:
MFCD00057144
UNSPSC Code:
41116107
PubChem Substance ID:
329815369
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CC(C(O)=O)c1ccc(cc1)N2Cc3ccccc3C2=O

InChI

1S/C17H15NO3/c1-11(17(20)21)12-6-8-14(9-7-12)18-10-13-4-2-3-5-15(13)16(18)19/h2-9,11H,10H2,1H3,(H,20,21)

InChI key

RJMIEHBSYVWVIN-UHFFFAOYSA-N

Gene Information

human ... IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

Application

Indoprofen is a non-steroidal drug, which can show a range of pharmacological properties such as analgesic and anti-inflammatory activities. Its mode of action involves the inhibition of prostaglandin synthesis.
Indoprofen may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using different chromatography techniques.
Indoprofen is a non-steroidal drug, which can show a range of pharmacological properties such as analgesic and anti-inflammatory activities.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H351

Precautionary Statements

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
127F0834V
127F0834
127F0834

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M Kurowski et al.
International journal of clinical pharmacology research, 8(4), 287-293 (1988-01-01)
Twenty-four patients suffering from rheumatoid arthritis and requiring articular punctures were treated with 200 mg of indoprofen thrice daily for four days. The subjects were divided into four groups each of six patients. Following the last dose, blood and synovial
B Przybilla et al.
Photo-dermatology, 4(2), 73-78 (1987-04-01)
The phototoxic activity of the non-steroidal anti-inflammatory drugs (NSAID) acetylsalicylic acid, benoxaprofen, carprofen, diclofenac, indoprofen, ketoprofen, tiaprofenic acid, and of thiophene, a heterocyclic ring structure of the tiaprofenic acid molecule, was evaluated in vitro by a newly developed photo-basophil-histamine-release test
Pharmacokinetics of the enantiomers of indoprofen in man
V T, et al.
International Journal of Clinical Pharmacology Research, 4(3), 223-230 (1984)
Determination of the enantiomers of indoprofen in blood plasma by high-performance liquid chromatography after rapid derivatization by means of ethyl chloroformate
Bjorkman S
Journal of Chromatography. B, Biomedical Applications, 339(2), 339-346 (1985)
Nicholas J Lawrence et al.
The Journal of organic chemistry, 67(2), 457-464 (2002-01-19)
The intermediate anion derived from the vicarious nucleophilic substitution (VNS) of hydrogen reacts with a series of alkyl halides to generate the corresponding alpha-alkylated conventional VNS product in a one-pot process. This one-pot VNS-alkylation reaction offers a convenient route to
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Chromatograms

application for HPLC

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