C4786

Cefoxitin sodium salt

• Empirical Formula (Hill Notation): C₁₆H₁₆N₃NaO₇S₂
• CAS Number: 33564-30-6
• Molecular Weight: 449.43
• EC Number: 251-574-6
• MDL number: MFCD00079042
• UNSPSC Code: 41116107
• PubChem Substance ID: 329775070
• NACRES: NA.24

Properties

• form: powder or granules
• Quality Level: 200
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule); veterinary
• storage temp.: 2-8°C
• SMILES string: [Na+].CO[C@]2(NC(=O)Cc1cccs1)C3SCC(COC(N)=O)=C(N3C2=O)C([O-])=O
• InChI: 1S/C16H17N3O7S2.Na/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19;/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22);/q;+1/p-1/t14-,16+;/m1./s1
• InChI key: GNWUOVJNSFPWDD-XMZRARIVSA-M

Description

General description

Cefoxitin is a β-lactam that belongs to the group of cephamycin antibiotics and is considered a 2^nd generation cephalosporin. It shows resistance to β-lactamases and is used to treat a broad spectrum of bacterial infections caused by gram-positive and gram-negative bacteria, such as bronchitis, pharyngitis, meningitis, and urinary tract infection among others. It is used for intravenous and intramuscular injections. It is found to be active against Bacteroides and is therapeutically used for the treatment of mixed aerobic-anaerobic infections.

Application

The analytical standard can be used to:

• Determine cefoxitin sodium using four stability-indicating spectrophotometric methods in the presence of its alkaline degradation products in its pure form and pharmaceutical dosage forms
• Separate and measure cefoxitin sodium in commercial drug products by high-performance liquid chromatography (HPLC)

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1B
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves