PX1000

o-Phosphoric Acid

85% W/W

• Synonym(s): Phosphoric acid, Orthophosphoric Acid, Orthophosphoric acid
• Linear Formula: H₃PO₄
• CAS Number: 7664-38-2
• Molecular Weight: 98.00
• Beilstein: 1921286
• MDL number: MFCD00011340
• UNSPSC Code: 12352301

Properties

• product name: o-Phosphoric Acid 85% W/W, 85% W/W
• vapor density: 3.4 (vs air)
• Quality Level: 200
• vapor pressure: 2.2 mmHg ( 20 °C); 5 mmHg ( 25 °C)
• form: liquid
• concentration: 85% phosphoric acid
• impurities: ≤0.001% Arsenic (As); ≤0.002% Heavy metals (as Pb)
• color: APHA: ≤40
• pH: <0.5 (20 °C, 100 g/L in H₂O)
• bp: 158 °C (lit.)
• mp: ~40 °C (lit.)
• density: 1.685 g/mL at 25 °C (lit.)
• shipped in: ambient
• storage temp.: room temp
• SMILES string: OP(O)(O)=O
• InChI: 1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)
• InChI key: NBIIXXVUZAFLBC-UHFFFAOYSA-N

Description

Application

• Development and validation of stability indicating UPLC methods for related substances and assay analyses of ricobendazole hydrochloride: This research employs o-Phosphoric acid 85% as a mobile phase component in ultra-performance liquid chromatography (UPLC) to analyze and validate the stability and purity of ricobendazole hydrochloride, crucial for pharmaceutical quality assurance. This method highlights the role of high-purity phosphoric acid in enhancing detection sensitivity and accuracy in pharmaceutical research (Ağtaş Ç, Bellur Atici E, Ayaz Seyhan S, Bilgic Alkaya D, 2024).


• Chemometrics-assisted development of a validated LC method for simultaneous estimation of temozolomide and γ-linolenic acid: This study showcases the application of o-Phosphoric acid 85% in liquid chromatography for the simultaneous estimation of temozolomide and γ-linolenic acid within lipidic nanoparticles. It emphasizes the acid′s role in improving chromatographic separation and analysis, critical for the advancement of nanomedicine and drug delivery systems (Beg S, Panda SS, Singh KK, 2022).

Other Notes

Concentrated phosphoric acid is approx. 85% H₃PO₄ (aqueous).

Analysis Note

Alkali phosphates: To pass test
Arsenic (As): 0.001% max
Assay: 85-88%
Color (APHA): 40 max
Description: To pass test
Form: Clear liquid
Heavy metals (as Pb): 0.002% max
Identification: To pass test
Nitrate: To pass test
Phosphorous or hypophosphorous acid: To pass test
Solubility: To pass test
Sulfate: To pass test

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H290,H302,H314
• Precautionary Statements: P234 - P270 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
• Storage Class Code: 8B - Non-combustible corrosive hazardous materials
• WGK: WGK 1
• Flash Point(F): does not flash
• Flash Point(C): does not flash