14-924-M
TYK2 Protein, active, 10 µg
Active, TN-terminal 6His-tagged, recombinant, human TYK2, amino acids 875-end. For use in Kinase Assays.
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10 μG
€460.00
250 μG
€3,770.00
€460.00
Estimated to ship on08 April 2025Details
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10 μG
€460.00
250 μG
€3,770.00
About This Item
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32
€460.00
Estimated to ship on08 April 2025Details
General description
Product Source: N-terminal 6His-tagged, recombinant, human TYK2 amino acids 875-end, expressed by baculovirus in Sf21 insect cells.
TYK2 is member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Application
Research Category
Signaling
Signaling
Biochem/physiol Actions
Protein Target: TYK2
Target Sub-Family: TK
Packaging
Also available in 250μg size as catalog # 14-924M and in bulk as catalog # 14-924-K.
Quality
Routinely evaluated by phosphorylation of peptide GGMEDIYFEFMGGKKK
Physical form
50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol
Purified using immobilized metal affinity chromatography followed by gel filtration.
Storage and Stability
6 months at -70°C
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Sens. 1
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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