07-1521

Anti-phospho-NDRG3 (Ser331) Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): Protein NDRG3, Protein Ndr3
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: horse, mouse
• species reactivity (predicted by homology): bovine (based on 100% sequence homology), equine (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rat (based on 100% sequence homology), human (based on 100% sequence homology)
• technique(s): western blot: suitable
• NCBI accession no.: NP_038893
• UniProt accession no.: Q9QYF9
• shipped in: wet ice
• target post-translational modification: phosphorylation (pSer331)
• Gene Information: bovine ... Ndrg3(514399) ; chimpanzee ... Ndrg3(735544) ; human ... NDRG3(57446) ; mouse ... Ndrg3(29812) ; rat ... Ndrg3(296318)

Description

General description

NDGR3 is a member of the N-myc down-regulated gene (NDGR) family which includes NDGR1-4. NDGR3 is ubiquitously expressed but is abundant in the brain, testis, prostate, and ovary. The precise role of NDGR3 has not been elucidated; however, previous studies have suggested that NDGR3 may play a role in spermatogenesis in mice, and aberrant expression of NDGR3 may lead to the proliferation of prostate cancer cells. NDGR3-mediated tumor growth may be due to upregulation of various angiogenic chemokines such as chemokine ligands 1, 3, and 5, which promote angiogenesis in tumors.

Specificity

This antibody recognizes NDRG3 phosphorylated at (Ser331).

Immunogen

Epitope: Phosphorylated (Ser331)

KLH-conjugated linear peptide corresponding to mouse NDRG3 phosphorylated at (Ser331).

Application

Detect phospho-NDRG3 (Ser331) using this Anti-phospho-NDRG3 (Ser331) Antibody validated for use in Western Blotting.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Quality

Evaluated by Western Blot in mouse embryonic fibroblast cell lysates under multiple conditions (see image).

Western Blot Analysis: 0.1 µg/mL of this antibody detected NDRG3 on 10 µg of mouse embryonic fibroblast cell lysates under multiple conditions (see image).

Target description

~33 kDa observed

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse embryonic fibroblast cell lysates under multiple conditions (see image).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable