131303P
Avanti
Cerebrosides (Brain)
Avanti Research™ - A Croda Brand
Synonym(s):
Total Cerebrosides (Brain, Porcine)
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25 MG
€209.00
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25 MG
€209.00
About This Item
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (131303P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Cerebrosides are glycosphingolipids with either glucose or galactose as a polar head group. They comprise the major component of the myelin lipids. Cerebrosides are part of non-neural cells including the epithelial cells associated with skin and the digestive system.[1] Cerebrosides are amphipathic in nature.[2]
The total brain cerebrosides appear as a double spot on thin layer chromatography (chloroform/methanol/water, 65:25:4 v/v). The top spot corresponds to ceresine which contain non-hydroxylated fatty acids, and the bottom spot corresponds to phrenosin which contain hydroxylated fatty acids.This Natural Lipid is a mixture and the structure shown above is only representative of one possible structure present in the product. Refer to chart for average fatty acid distribution.
Application
Biochem/physiol Actions
Cerebrosides regulate a variety of physiological processes like cell growth, survival and multiplication. They coordinate membrane trafficking and inhibit apoptosis. Inborn metabolic disorder, Gaucher′s disease is associated with elevated levels of cerebrosides.[6]. Additionally, cerebrosides provide structural support to the membranes and mediate intracellular communication.[2] Accumulation of galactocerebrosides is associated with tumors. It also serves as a receptor for human immune deficiency virus (HIV) glycoprotein.[6] The porcine cerebroside and ganglioside (CPCG) is used in treating neurotoxicity induced by the drug oxaliplatin in digestive system tumors.[7]
Packaging
5 mL Amber Glass Screw Cap Vial (131303P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
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