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W779547

Sigma-Aldrich

γ-Cyclodextrin

produced by Wacker Chemie AG, Burghausen, Germany, ≥98% (on dry basis)

Synonym(s):

Cavamax® W8, Cyclomaltooctaose, Cyclooctaamylose, Schardinger γ-Dextrin

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About This Item

Empirical Formula (Hill Notation):
C48H80O40
CAS Number:
Molecular Weight:
1297.12
Beilstein:
78740
EC Number:
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22

grade

produced by Wacker Chemie AG, Burghausen, Germany

reg. compliance

FDA 21 CFR 117

description

derived from GMO corn

Assay

≥98% (on dry basis)

impurities

≤0.5% reducing substances (determined as dextrose)
≤1.000 microorganisms per g
≤11% water
≤20 ppm volatile organics
≤5 ppm heavy metals
0 salmonella / E. Coli in 10 g

ign. residue

≤0.1%

cation traces

As: ≤1.3 ppm
Pb: ≤1 ppm

SMILES string

[H][C@]1(O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@@H]2[C@@H](COC(C)=O)O[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O

InChI

1S/C48H80O40/c49-1-9-33-17(57)25(65)41(73-9)82-34-10(2-50)75-43(27(67)19(34)59)84-36-12(4-52)77-45(29(69)21(36)61)86-38-14(6-54)79-47(31(71)23(38)63)88-40-16(8-56)80-48(32(72)24(40)64)87-39-15(7-55)78-46(30(70)22(39)62)85-37-13(5-53)76-44(28(68)20(37)60)83-35-11(3-51)74-42(81-33)26(66)18(35)58/h9-72H,1-8H2/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m1/s1

InChI key

GDSRMADSINPKSL-HSEONFRVSA-N

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Application

γ-Cyclodextrin (γ-CD), a water-soluble cyclic oligosaccharide consisting of eight α-(1,4)-linked glucopyranose subunits, can be used in a wide range of applications including:
  • Synthesis of renewable and biocompatible metal-organic frameworks.
  • Formation of inclusion complexes with a variety of guest molecules to increase their solubility in water and other polar solvents.
  • Synthesis of γ-CD based nanogels and dendrimers as carriers and stabilizers for drug delivery applications.

Legal Information

Cavamax is a registered trademark of Wacker Chemie AG

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cyclodextrin-mediated enhancement of riboflavin solubility and corneal permeability.
Morrison, Peter WJ et al.
Angewandte Chemie (International Edition in English), 10(2), 756-762 (2013)
Cross-linked hydroxypropyl-β-cyclodextrin and γ-cyclodextrin nanogels for drug delivery: physicochemical and loading/release properties.
Moya-Ortega, Maria D et al.
Carbohydrate Polymers, 87(3), 2344-2351 (2012)
Cyclodextrin functionalized graphene nanosheets with high supramolecular recognition capability: synthesis and host- guest inclusion for enhanced electrochemical performance.
Guo, Yujing et al.
ACS Nano, 4(7), 4001-4010 (2010)
Metal-organic frameworks from edible natural products.
Smaldone, Ronald A et al.
Angewandte Chemie (International Edition in English), 49(46), 8630-8634 (2010)
Phatsawee Jansook et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 13(3), 336-350 (2010-11-26)
Study the complexation of dexamethasone in combinations of γ-cyclodextrin (γCD) and 2-hydroxypropyl-γ-cyclodextrin (HPγCD) with emphasis on solid characterization and development of aqueous dexamethasone eye drop suspension for drug delivery through sclera. Dexamethasone/cyclodextrin (dexamethasone/CD) solid complex systems were prepared and characterized

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