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A50606

Sigma-Aldrich

6-Aminouracil

97%

Synonym(s):

4-Amino-2,6-dihydroxypyrimidine, 6-Amino-2,4-pyrimidinediol

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100 G
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100 G
€38.90

About This Item

Empirical Formula (Hill Notation):
C4H5N3O2
CAS Number:
Molecular Weight:
127.10
Beilstein:
120491
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

€38.90


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Quality Level

Assay

97%

form

powder

mp

≥360 °C (lit.)

SMILES string

Nc1cc(O)nc(O)n1

InChI

1S/C4H5N3O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H4,5,6,7,8,9)

InChI key

LNDZXOWGUAIUBG-UHFFFAOYSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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P M Tarantino et al.
Journal of medicinal chemistry, 42(11), 2035-2040 (1999-06-04)
6-Anilinouracils (6-AUs) are dGTP analogues which selectively inhibit the DNA polymerase III of Bacillus subtilis and other Gram-positive bacteria. To enhance the potential of the 6-AUs as antimicrobial agents, a structure-activity relationship was developed involving substitutions of the uracil N3
K Hirota et al.
Nucleic acids symposium series, (37)(37), 59-60 (1997-01-01)
Inhibitors of thymidine phosphorylase (dThdPase) are expected to suppress the growth and metastasis of tumor cells by inhibition of angiogenesis and were designed by utilizing the three dimensional structure of the enzyme. 5-Substituted 6-aminouracils (5) and 7-substituted pyrrolo[2,3-d]pyrimidine-2,4-diones (6) were
Kyung Mee Kim et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(1-2), 65-70 (2008-12-17)
Uric acid (UA) can be directly converted to allantoin enzymatically by uricase in most mammals except humans or by reaction with superoxide. UA can react directly with nitric oxide to generate 6-aminouracil and with peroxynitrite to yield triuret; both of
Christine Gersch et al.
Nucleosides, nucleotides & nucleic acids, 27(8), 967-978 (2008-08-13)
The 1980 identification of nitric oxide (NO) as an endothelial cell-derived relaxing factor resulted in an unprecedented biomedical research of NO and established NO as one of the most important cardiovascular, nervous and immune system regulatory molecule. A reduction in
H Sladowska et al.
Acta poloniae pharmaceutica, 53(1), 39-46 (1996-01-01)
Synthesis of 6-substituted 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidines [III-VI] obtained by cyclocondensation of 1-phenyl-6-aminouracil with formaline and the primary amines is described. Compounds III, V, VI in the Mannich reaction with secondary cyclic amines yield the corresponding 3-substituted N-aminomethyl derivatives VII-X. Some of them

Questions

  1. Is 6-aminouracil autoclavable?

    1 answer
    1. The autoclavability of this compound has not been determined. As a precaution, it may be best to sterile filter stock solutions.

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