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795291

Sigma-Aldrich

Phenofluor™ solution

0.1 M in toluene

Synonym(s):

1,3-Bis(2,6-diisopropylphenyl)-2,2-difluoro-4-imidazoline

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About This Item

Empirical Formula (Hill Notation):
C27H36F2N2
Molecular Weight:
426.58
MDL number:
MFCD22377831
UNSPSC Code:
12352101
PubChem Substance ID:
329768478
NACRES:
NA.22

form

liquid

Quality Level

100

concentration

0.1 M in toluene

density

0.865 g/mL at 25 °C

storage temp.

2-8°C

InChI

1S/C27H36F2N2/c1-17(2)21-11-9-12-22(18(3)4)25(21)30-15-16-31(27(30,28)29)26-23(19(5)6)13-10-14-24(26)20(7)8/h9-20H,1-8H3

InChI key

FQXXWTOSPDVNSG-UHFFFAOYSA-N

Application

Facile deoxyfluorination of phenols without preactivation (), along with highly chemoselective deoxyfluorination of highly functionalized late-stage intermediates ().

Legal Information

PhenoFluor is a trademark of SciFluor Life Sciences, LLC
PhenoFluor is a trademark of SciFluor Life Sciences, LLC

related product

Product No.
Description
Pricing

900456

AlkylFluor

Signal Word

Danger

Hazard Classifications

Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

39.2 °F

Flash Point(C)

4 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Filippo Sladojevich et al.
Journal of the American Chemical Society, 135(7), 2470-2473 (2013-02-13)
An operationally simple protocol for the selective deoxyfluorination of structurally complex alcohols is presented. Several fluorinated derivatives of natural products and pharmaceuticals have been prepared to showcase the potential of the method for late-stage diversification and its functional group compatibility.
Pingping Tang et al.
Journal of the American Chemical Society, 133(30), 11482-11484 (2011-07-09)
An operationally simple ipso fluorination of phenols with a new deoxyfluorination reagent is presented.

Articles

PhenoFluor™ Deoxyfluorination Solution

PhenoFluor™ enables one-step conversion of phenols to aryl fluorides, facilitating fluorination without pre-activation.

Related Content

Ritter Group – Professor Product Portal

The Ritter lab currently focuses on fluorination chemistry for late-stage functionalization of complex natural and unnatural products. PhenoFluor™ has been developed as a general reagent for the selective, predictable, direct deoxyfluorination of complex alcohols and phenols.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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