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708496

Sigma-Aldrich

Acetyl chloride solution

1 M in methylene chloride

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100 ML
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About This Item

Empirical Formula (Hill Notation):
C2H3ClO
CAS Number:
75-36-5
Molecular Weight:
78.50
MDL number:
MFCD00000719
UNSPSC Code:
12352101
PubChem Substance ID:
329762802
NACRES:
NA.22

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form

liquid

Quality Level

100

concentration

1 M in methylene chloride

refractive index

n20/D 1.423

density

1.294 g/mL at 25 °C

functional group

acyl chloride

SMILES string

CC(Cl)=O

InChI

1S/C2H3ClO/c1-2(3)4/h1H3

InChI key

WETWJCDKMRHUPV-UHFFFAOYSA-N

Related Categories

Application

Acetyl chloride (AcCl) can be used as:
  • An acylating reagent to prepare useful key intermediates in organic synthesis.[1][2]
  • A reagent to convert oxathioacetals and dithioacetals into corresponding carbonyl compounds in the presence of sodium nitrite.[3]
  • An activating or acylating reagent in solid-phase organic synthesis.[4]
  • A reagent to prepare various alkyl and aryl tetrahydropyranyl ethers from corresponding alcohols.[5]

Signal Word

Danger

Hazard Statements

H225,H314,H336,H351

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT8647
MKCL1414
MKCJ6496
MKCC7802
MKBX1975V

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New phenylfluorenyl based linkers for solid phase synthesis
Bleicher KH, et al.
Tetrahedron Letters, 41(47), 9037-9042 (2000)
Selective synthesis of spirooxindoles via a two-step reaction of N-phenacylpyridinium bromide, 1, 3-indanedione and N-alkylisations
Sun J, et al.
Organic & Biomolecular Chemistry, 17(16), 3978-3983 (2019)
Solid phase synthesis of styrylquinazolinones
Theoclitou M-E, et al.
Tetrahedron Letters, 41(13), 2051-2054 (2000)
A highly efficient procedure for regeneration of carbonyl groups from their corresponding oxathioacetals and dithioacetals using sodium nitrite and acetyl chloride in dichloromethane
Khan AT, et al.
Synlett, 2003(03), 0377-0381 (2003)
Acetyl chloride-mediated mild and chemoselective attachment and removal of tetrahydropyranyl (THP) group
Yeom C-E, et al.
Bulletin of the Korean Chemical Society,, 28(1), 103-107 (2007)
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