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Sigma-Aldrich

Ritalinic acid

99% (CP)

Synonym(s):

a-Phenyl-2-piperidineacetic acid

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About This Item

Empirical Formula (Hill Notation):
C13H17NO2
CAS Number:
Molecular Weight:
219.28
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.12

Quality Level

Assay

99% (CP)

SMILES string

OC(=O)C(C1CCCCN1)c2ccccc2

InChI

1S/C13H17NO2/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16)

InChI key

INGSNVSERUZOAK-UHFFFAOYSA-N

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Packaging

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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Marion Letzel et al.
Chemosphere, 81(11), 1416-1422 (2010-10-12)
To investigate the occurrence and fate of ritalinic acid - the main human metabolite of the psychostimulant drug methylphenidate - in the aquatic environment, a HPLC-electrospray-MS/MS method for the quantification of ritalinic acid in wastewater, surface water and bank filtrate
T Aoyama et al.
Journal of pharmaceutical sciences, 79(6), 465-469 (1990-06-01)
A gas chromatographic-mass spectrometric method was developed for the stereoselective quantification of threo-methylphenidate (MPD) and its metabolite, ritalinic acid (RA), in plasma or urine. The plasma concentrations of (+)-MPD after oral administration of two 10-mg conventional tablets containing racemic MPD.HCl
A Solans et al.
Journal of chromatography. B, Biomedical applications, 658(2), 380-384 (1994-08-19)
Two analytical methods for the simultaneous detection in urine of methylphenidate and its main metabolite, ritalinic acid, are described. Both procedures are based on solid-phase extraction of urine samples on Bond Elut Certify columns, and capillary gas chromatographic-mass spectrometric detection
J S Markowitz et al.
Journal of clinical psychopharmacology, 19(4), 362-366 (1999-08-10)
Methylphenidate is the most commonly prescribed psychostimulant in clinical use today. Known methylphenidate metabolites include ritalinic acid, corresponding lactams, and p-hydroxymethylphenidate. Recent in vitro work using rat liver preparations has indicated that the methylphenidate ethyl ester, ethylphenidate, is formed upon
N R Srinivas et al.
Journal of chromatography, 530(2), 327-336 (1990-09-14)
Enantioselective gas chromatographic assays for the quantitation of methylphenidate and its major metabolite ritalinic acid in plasma are described. The procedures involved the extraction of methylphenidate enantiomers from alkanised plasma. The plasma was then washed to ensure complete removal of

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