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348147

Sigma-Aldrich

Sarsasapogenin

95%

Synonym(s):

(25S)-Spirostan-3β-ol, Parigenin

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About This Item

Empirical Formula (Hill Notation):
C27H44O3
CAS Number:
126-19-2
Molecular Weight:
416.64
MDL number:
MFCD00270414
UNSPSC Code:
12352200
PubChem Substance ID:
329755058

Assay

95%

form

solid

SMILES string

C[C@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C

InChI

1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

InChI key

GMBQZIIUCVWOCD-WWASVFFGSA-N

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Yaer Hu et al.
Neurobiology of aging, 31(6), 1010-1019 (2008-08-05)
The purpose of this work is to study the effect of smilagenin on the mRNA stability of muscarinic receptor subtype 1 (M(1); m1 mRNA) in aged rat brains and its significance in improving memory. The Y-maze avoidance task showed that
Xue-Feng Huang et al.
Journal of integrative plant biology, 50(6), 717-722 (2008-08-21)
One new (Sarsasapogenin O) and seven known steroids were isolated from the roots of Asparagus officinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known
Hua Zhou et al.
Molecular and cellular endocrinology, 270(1-2), 17-22 (2007-03-17)
We investigated the effect of tigogenin on adipocytic and osteoblastic differentiation in mouse bone marrow stromal cells (BMSCs). Tigogenin enhanced the proliferation of BMSCs significantly. Tigogenin treatment reduced the adipogenic induction of lipid accumulation, visfatin secretion, and the expressions of
Haiyan Hu et al.
FEBS letters, 584(8), 1549-1552 (2010-03-11)
This work studied the role of cyclic AMP responsive element binding protein (CREB) in the up-regulation of M(1) muscarinic acetylcholine receptor (M(1) receptor) density by sarsasapogenin (ZMS) in CHO cells transfected with M(1) receptor gene (CHOm1 cells). During cell aging
Bertrand Liagre et al.
International journal of molecular medicine, 20(4), 451-460 (2007-09-06)
We conducted our study to assess the antiproliferative and proapoptotic potential of hecogenin and tigogenin, two saponins which are structurally similar to diosgenin. We particularly focused our attention on mitogen-activated protein kinase (MAPK) activation in relation to apoptosis but also
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