T9299
β-(1,2,4-Triazol-3-yl)-DL-alanine
≥98% (TLC)
Synonym(s):
(±)-2-Amino-3-(1,2,4-triazol-3-yl)propionic acid, DL-1,2,4-Triazole-3-alanine
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All Photos(4)
About This Item
Empirical Formula (Hill Notation):
C5H8N4O2
CAS Number:
Molecular Weight:
156.14
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
Pricing and availability is not currently available.
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Product Name
β-(1,2,4-Triazol-3-yl)-DL-alanine,
Assay
≥98% (TLC)
Quality Level
form
powder
color
white to off-white
storage temp.
−20°C
SMILES string
NC(Cc1nc[nH]n1)C(O)=O
InChI
1S/C5H8N4O2/c6-3(5(10)11)1-4-7-2-8-9-4/h2-3H,1,6H2,(H,10,11)(H,7,8,9)
InChI key
CAPORZWUTKSILW-UHFFFAOYSA-N
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Linkage
Inhibitory histidine analog.
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P Soumillion et al.
Protein engineering, 11(3), 213-217 (1998-06-05)
The only histidine residue in the H31N-H137N double mutant of phage lambda lysozyme (lambdaL), at position 48, was biosynthetically replaced by the analogue 1,2,4-triazole-3-alanine (Taz), the basicity of which is 3 pKa units lower. A histidine-auxotrophic strain was grown to
Yutaka Ikeda et al.
Protein engineering, 16(9), 699-706 (2003-10-16)
Proteins containing unnatural amino acids have immense potential in biotechnology and medicine. We prepared several histidine analogues including a novel histidine analogue, beta-(1,2,3-triazol-4-yl)-DL-alanine. These histidine analogues were assayed for translational activity in histidine-auxotrophic Escherichia coli strain UTH780. We observed that
Younas Aouine et al.
Molecules (Basel, Switzerland), 16(4), 3380-3390 (2011-04-23)
A simple synthetic approach to racemic N-tert-butyloxycarbonyl-2-methyl-3-(1H-1,2,4-triazol-1-yl)alanine (5) in four steps and 68% overall yield starting from oxazoline derivative 1 is reported. This synthesis involves the alkylation of 1H-1,2,4-triazole with an O-tosyloxazoline derivative, followed by an oxazoline ring-opening reaction and
S H Beiboer et al.
Protein engineering, 9(4), 345-352 (1996-04-01)
The effect of the substitution of the active site histidine 48 by the unnatural 1,2,4-triazole-3-alanine (TAA) amino acid analogue in porcine pancreas phospholipase A2 (PLA2) was studied. TAA was introduced biosynthetically using a his-auxotrophic Escherichia coli strain. To study solely
K A Sment et al.
Applied and environmental microbiology, 55(5), 1295-1297 (1989-05-01)
In contrast to wild-type cells, it was found that triazole-alanine-resistant mutants of Methanococcus voltae excreted histidine, proline, phenylalanine, and tyrosine in various combinations. These results suggest that a form of general amino acid biosynthetic control may operate in this methanogen.
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