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T8931
Thyrotropic hormone from bovine pituitary
Synonym(s):
TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands
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About This Item
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biological source
bovine pituitary glands
Quality Level
form
powder
packaging
vial of 100 μg
technique(s)
cell culture | mammalian: suitable
storage temp.
2-8°C
Gene Information
cow ... TSHB(281552)
human ... TSHR(7253)
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General description
Application
Thyrotropic hormone from bovine pituitary has been used:
- to induce cAMP production in orbital fibroblasts.[4]
- as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.[5]
- for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.[6]
- for studying the thyrotropin involvement in photoperiodic signal transduction in mice.[7]
Biochem/physiol Actions
Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function.[8] In children, TSH plays a vital role in normal cognition and neurodevelopment.[9] Circulating TSH is capable of binding to cell surface receptors in the thyroid gland.[2] This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer.[10] It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.[11]
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Quality
Contains phosphate buffer salts
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy
Turcu AF, et al.
The Journal of Clinical Endocrinology and Metabolism, 98(5), 2153-2159 (2013)
Gen Hiyama et al.
Scientific reports, 8(1), 10012-10012 (2018-07-04)
Biased mating due to female preferences towards certain traits in males is a major mechanism driving sexual selection, and may constitute an important evolutionary force in organisms with sexual reproduction. In birds, although the role of male ornamentation, plumage coloration
Pituitary, Thyroid, and Parathyroid Pharmacology
Galasko GT
Pharmacology and Therapeutics for Dentistry, 417-428 (2017)
Dong Lin et al.
Journal of cellular physiology, 237(1), 868-880 (2021-08-27)
Diabetic retinopathy (DR) is a common complication of diabetes mellitus. High glucose-induced mitochondrial apoptosis is involved in the loss of retinal pericytes (PCs), which is considered to be a predominant pathologic change of diabetic retinopathy (DR). A high thyroid stimulating
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こちらの製品の使用期限を教えてください。 製品：T8931-10VL Source：SLCL1077 よろしくお願いいたします。
1 answer-
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Without IU, what concentration in mg/ml is typically used in thyroid cell culture?
1 answer-
Historically, the activity of this product was determined to have a range of 1.5 - 2.5 IU/mg protein. This product has not been screened for activity for a number of years. There are publications citing the use of bovine TSH in uM concentrations. Please see the link below to review an example:
https://www.ahajournals.org/doi/pdf/10.1161/01.atv.0000102520.84030.a1To review a sample Certificate of Analysis for this product, please see the link below:
https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/T8931-BULK0000257036.pdfAlternatively, product T9265, a human source TSH, is tested for unit activity. Should this product be of interest, please see the link below:
https://www.sigmaaldrich.com/product/sigma/t9265Helpful?
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Which is the units content of 100 ug of this product? thank you very much
1 answer-
The unit activity for item T8931, Thyrotropic hormone from bovine pituitary, is not specified.
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