Sodium channel epithelial 1 β subunit (SCNN1B) is expressed in the posterior cerebral artery of rats. It is one of the subunits of epithelial sodium channels. The gene ID of the protein is 24767.
Specificity
Detects ~87 kDa.
Immunogen
AA617–638 of the rat sequence
Biochem/physiol Actions
Sodium channel epithelial 1 β subunit (SCNN1B) is involved in sodium transport in the epithelium.
Features and Benefits
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Physical form
PBS, 50% glycerol, and 0.09% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
American journal of physiology. Renal physiology, 312(4), F682-F688 (2017-04-04)
Mice transgenic for genomic segments harboring PHAII (pseudohypoaldosteronism type II) mutant Wnk4 (with-No-Lysine kinase 4) (TgWnk4PHAII) have hyperkalemia which is currently believed to be the result of high activity of Na-Cl cotransporter (NCC). This leads to decreasing Na+ delivery to
Journal of the American Society of Nephrology : JASN, 26(11), 2678-2690 (2015-04-08)
Kcnj10 encodes the inwardly rectifying K(+) channel Kir4.1 in the basolateral membrane of the distal convoluted tubule (DCT) and is activated by c-Src. However, the regulation and function of this K(+) channel are incompletely characterized. Here, patch-clamp experiments in Kcnj10-transfected
It has been suggested that mechanosensitive ion channels initiate myogenic responses in vessels; however, the molecular identity of the mechanosensitive ion channel complex is unknown. Although previous reports have suggested that epithelial Na(+) channel (ENaC) proteins are mechanotransducers in arteries
Frontiers in pharmacology, 12, 665111-665111 (2021-06-15)
The use of cyclosporine A (CsA) in transplant recipients is limited due to its side effects of causing severe hypertension. We have previously shown that CsA increases the activity of the epithelial sodium channel (ENaC) in cultured distal nephron cells.
Adverse effect of assisted reproductive technology-related hyperoestrogensim on the secretion and absorption of uterine fluid in superovulating mice during the peri-implantation period.
Xia, et al.
Frontiers in Endocrinology, 14, 859204-859204 (2023)
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