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Key Documents

RDD022

Sigma-Aldrich

Sodium phosphate dibasic

anhydrous, free-flowing, Redi-Dri, ReagentPlus®, ≥99.0%

Synonym(s):

sec-Sodium phosphate, Disodium hydrogen phosphate, Disodium phosphate, Sodium hydrogenphosphate

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About This Item

Linear Formula:
Na2HPO4
CAS Number:
Molecular Weight:
141.96
EC Number:
MDL number:
UNSPSC Code:
12161700
PubChem Substance ID:
NACRES:
NA.25

grade

anhydrous

Quality Level

product line

ReagentPlus®
Redi-Dri

Assay

≥99.0%

form

powder

quality

free-flowing

loss

≤1.0% loss on drying

pH

8.9-9.2 (25 °C, 50 g/L in water)

pKa (25 °C)

(1) 2.15, (2) 6.82, (3) 12.38 (phosphoric acid)

solubility

water: 100 mg/mL, clear, colorless

SMILES string

[Na+].[Na+].[H]OP([O-])([O-])=O

InChI

1S/2Na.H3O4P/c;;1-5(2,3)4/h;;(H3,1,2,3,4)/q2*+1;/p-2

InChI key

BNIILDVGGAEEIG-UHFFFAOYSA-L

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General description

Sodium phosphate dibasic is a commonly used buffer in frozen formulations.

Application


  • Solid-State NMR Spectroscopy to Probe State and Phase Transitions in Frozen Solutions: This study utilized Sodium phosphate dibasic in the development of formulations for solid-state NMR spectroscopy, focusing on its utility in stabilizing and buffering various chemical environments within in vitro diagnostics manufacturing. This application ensures precise diagnostics by maintaining the integrity of the solution during freezing and thawing cycles (Du et al., 2023).

  • Arabinoxylan in Water through SANS: Single-Chain Conformation, Chain Overlap, and Clustering: This paper discusses the application of Sodium phosphate dibasic in the creation of specific buffer solutions for the structural analysis of polysaccharides using small-angle neutron scattering (SANS), a technique often employed in the pharmaceutical and biotechnological industries to ensure high-quality standards in diagnostics production (Petermann et al., 2023).

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Teddy J Zbacnik et al.
Journal of pharmaceutical sciences, 106(3), 713-733 (2016-11-30)
Buffers comprise an integral component of protein formulations. Not only do they function to regulate shifts in pH, they also can stabilize proteins by a variety of mechanisms. The ability of buffers to stabilize therapeutic proteins whether in liquid formulations

Articles

Redi-Dri™ prevents hygroscopic powders, such as inorganic salts, from absorbing moisture and forming clumps, leaving the salts free-flowing every time.

Redi-Dri™ prevents hygroscopic powders, such as inorganic salts, from absorbing moisture and forming clumps, leaving the salts free-flowing every time.

Redi-Dri™ prevents hygroscopic powders, such as inorganic salts, from absorbing moisture and forming clumps, leaving the salts free-flowing every time.

Redi-Dri™ prevents hygroscopic powders, such as inorganic salts, from absorbing moisture and forming clumps, leaving the salts free-flowing every time.

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