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R9525

Sigma-Aldrich

RX 821002 hydrochloride

solid, ≥98% (HPLC)

Synonym(s):

2-[2-(2-Methoxy-1,4-benzodioxanyl)]imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H14N2O3 · HCl
CAS Number:
109544-45-8
Molecular Weight:
270.71
MDL number:
MFCD00069343
UNSPSC Code:
12352200
PubChem Substance ID:
24278684
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: >20 mg/mL

SMILES string

Cl[H].COC1(COc2ccccc2O1)C3=NCCN3

InChI

1S/C12H14N2O3.ClH/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12;/h2-5H,6-8H2,1H3,(H,13,14);1H

InChI key

IMPOOMVZVWKSAP-UHFFFAOYSA-N

Gene Information

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Biochem/physiol Actions

Selective α2-adrenoceptor antagonist

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000395015
0000395015
027M4717V
010M4616V

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J Galitzky et al.
British journal of pharmacology, 100(4), 862-866 (1990-08-01)
1. The binding of a new alpha 2-adrenoceptor antagonist, [3H]-RX821002 (2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline), was investigated in human platelet membranes and compared with [3H]-yohimbine binding parameters. 2. Analysis of kinetic data revealed association and dissociation time courses consistent with a simple biomolecular reaction.
S J Rayment et al.
British journal of pharmacology, 160(7), 1727-1740 (2010-07-24)
We have investigated the distribution of alpha-adrenoceptors in sheep internal anal sphincter (IAS), as a model for the human tissue, and evaluated various imidazoline derivatives for potential treatment of faecal incontinence. Saturation and competition binding with (3)H-prazosin and (3)H-RX821002 were
S Gasparini et al.
Neuroscience, 164(2), 370-379 (2009-09-01)
The blockade of serotoninergic receptors with methysergide or the activation of alpha(2)-adrenoceptors with moxonidine into the lateral parabrachial nucleus (LPBN) increases water and 0.3 M NaCl intake in rats treated with furosemide (FURO) combined with captopril (CAP). In the present
R L Almeida et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 301(1), R185-R192 (2011-04-09)
Lipopolysaccharide (LPS), an endotoxin from the wall of Escherichia coli, produces a general behavioral inhibition and affects several aspects of fluid-electrolyte balance. LPS inhibits thirst; however, it is not clear if it also inhibits sodium appetite. The present results show
Thiago Roberto Lima Romero et al.
European journal of pharmacology, 608(1-3), 23-27 (2009-02-25)
Xylazine is an alpha(2)-adrenoceptor agonist extensively used in veterinary and animal experimentation. Evidence exists that alpha(2)-adrenoceptor agonists can activate opioid receptors via endogenous opioid release. Considering this idea and the multiple alpha(2) subtypes currently known (alpha(2A), alpha(2B), alpha(2C) and alpha(2D))
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