Unfortunately, the solution stability of this product has not been determined. However, historical information on a previously deleted option indicates that solutions in water may be stored for up to 1 month and solutions in DMSO may be stored for up to 6 months at - 20°C, in aliquots. Avoid repeated freeze/thaw cycles.
PZ0178
PHA 767491 hydrochloride
≥98% (HPLC)
Synonym(s):
1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride, PHA-00767491 hydrochloride
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C12H11N3O · xHCl
CAS Number:
Molecular Weight:
213.24 (free base basis)
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
off-white to yellow
solubility
H2O: >25 mg/mL
SMILES string
Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3
InChI
1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H
InChI key
IMVNFURYBZMFDZ-UHFFFAOYSA-N
Application
Biochem/physiol Actions
PHA 767491 serves as a potential anticancer drug.[3] It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect.[4]
PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9.
PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Medicinal Chemistry: Fusion of Traditional and Western Medicine, 382-382 (2014)
Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage
Stork CT, et al.
eLife, 5, e17548-e17548 (2016)
The Initiation of DNA Replication in Eukaryotes, 289-289 (2016)
Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses
Hamper S, et al.
Cell, 170(4), 774-786 (2017)
Irene Gallina et al.
Molecular cell, 81(3), 442-458 (2020-12-16)
Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of unreplicated single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication. Gap-filling synthesis involves either translesion DNA synthesis (TLS)
Articles
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
Review properties, activators and inhibitors, and available products for researching cyclin-dependent kinases (CDKs).
-
시약 보관 온도 문의드립니다. H2O에 녹인 후에 -20'C에 보관하면 되는걸까요?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
