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N1514

Sigma-Aldrich

Nervonic acid

≥99% (capillary GC)

Synonym(s):

cis-15-Tetracosenoic acid, Selacholeic acid

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About This Item

Linear Formula:
CH3(CH2)7CH=CH(CH2)13COOH (cis)
CAS Number:
506-37-6
Molecular Weight:
366.62
Beilstein:
1728551
MDL number:
MFCD00010507
UNSPSC Code:
12352211
PubChem Substance ID:
24897496
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

plant

Assay

≥99% (capillary GC)

form

powder

mp

42-43 °C (lit.)

functional group

carboxylic acid

lipid type

unsaturated FAs

shipped in

ambient

storage temp.

−20°C

SMILES string

CCCCCCCC\C=C/CCCCCCCCCCCCCC(O)=O

InChI

1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9-

InChI key

GWHCXVQVJPWHRF-KTKRTIGZSA-N

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Application

Nervonic acid has been used as a synthetic lipid supplement in vitro to study about effect of the developmental diet in Drosophila lifespan.[1]

Biochem/physiol Actions

Nervonic acid (C24:1), a component of membrane sphingolipids and phosphatidylethanolamines, may be a useful predictor of chronic kidney disease mortality and diabetes. Nervonic acid oils are being studied for pharmaceutical, nutraceutical and industrial applications. Nervonic acid is a major component of Lunaria oil.

Packaging

Sealed ampule.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV0166
MKCS7765
MKCR9631
MKCS0794
MKCR0461

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Developmental diet regulates Drosophila lifespan via lipid autotoxins
Stefana MI, et al.
Nature Communications, 8(1), 1384-1384 (2017)
Y Mizushina et al.
Journal of molecular biology, 304(3), 385-395 (2000-11-25)
Unsaturated long-chain fatty acids selectively bind to the DNA binding sites of DNA polymerase beta and DNA topoisomerase II, and inhibit their activities, although the amino acid sequences of these enzymes are markedly different from each other. Computer modeling analysis
Arja T Erkkilä et al.
The Journal of craniofacial surgery, 16(5), 764-769 (2005-09-30)
The fatty acid profiles of serum lipids were examined in 53 ten-year-old cleft children. The children presented with different cleft types (cleft lip, cleft lip and palate, isolated cleft palate and submucuous cleft palate) and were recruited from the Finnish
Gregory C Shearer et al.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 22(2), 277-283 (2011-07-22)
Although the value of red blood cell fatty acids (FAs) in estimating risk for acute coronary syndrome in the general population is evident, the value of FAs in chronic kidney disease (CKD) is unknown. Here, we provide a pilot analysis
Peroxisomal fatty acid oxidation and cellular redox.
Inderjit Singh
Methods in enzymology, 352, 361-372 (2002-07-20)
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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