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K3250

Sigma-Aldrich

Kynuramine dihydrobromide

monoamine oxidase substrate, fluorogenic, ≥97% (TLC), crystalline

Synonym(s):

3-(2-Aminophenyl)-3-oxopropanamine

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About This Item

Empirical Formula (Hill Notation):
C9H12N2O · 2HBr
CAS Number:
304-47-2
Molecular Weight:
326.03
MDL number:
MFCD00050683
UNSPSC Code:
12352204
PubChem Substance ID:
24896227
NACRES:
NA.32

product name

Kynuramine dihydrobromide, crystalline

Assay

≥97% (TLC)

Quality Level

100

form

crystalline

solubility

water: 50 mg/mL, clear to slightly hazy

storage temp.

−20°C

SMILES string

Br.NCCC(=O)c1ccccc1N

InChI

1S/C9H12N2O.BrH/c10-6-5-9(12)7-3-1-2-4-8(7)11;/h1-4H,5-6,10-11H2;1H

InChI key

YUPVVZSYBUIDQR-UHFFFAOYSA-N

Application

Kynuramine dihydrobromide has been used as a substrate for monoamine oxidase.

Biochem/physiol Actions

Kynuramine dihydrobromide is a substrate for the enzyme monoamine oxidase. The end product is the formation of fluorescence detectable 4-hydroxyquinoline (4-HOQ) measured in a fluorescence spectrophotometer at 380 nm.

Substrates

Substrate for monoamine oxidase

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhanna V Chirkova et al.
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Hit, Lead & Candidate Discovery In recent studies, we have shown that pyrrolo[3,4-f]indole-5,7-dione and indole-5,6-dicarbonitrile derivatives act as good potency in vitro inhibitors of the monoamine oxidase (MAO) enzymes. To expand on these series and to further derive structure-activity relationships
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Berntssen MHG, et al.
Aquatic Toxicology (Amsterdam, Netherlands), 65(1), 55-72 (2003)
Magdalena S Nel et al.
Bioorganic chemistry, 69, 20-28 (2016-09-24)
In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. These compounds are structurally related to series of heterocyclic chalcone derivatives which have previously been
M Figueiredo-González et al.
Food research international (Ottawa, Ont.), 106, 558-567 (2018-03-28)
In this work, phenol-rich extracts from 'Cornicabra' and 'Picual' virgin-olive oils (EVOOs) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in Alzheimer's disease (AD) (acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and 5-lipoxygenase (LOX)), major depressive
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