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C7956

Sigma-Aldrich

Coenzyme Q1

≥95%

Synonym(s):

2,3-Dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone, Ubiquinone-1, Ubiquinone-5

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About This Item

Empirical Formula (Hill Notation):
C14H18O4
CAS Number:
Molecular Weight:
250.29
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.51
Pricing and availability is not currently available.

Quality Level

Assay

≥95%

form

liquid

storage temp.

−20°C

SMILES string

COC1=C(OC)C(=O)C(C\C=C(\C)C)=C(C)C1=O

InChI

1S/C14H18O4/c1-8(2)6-7-10-9(3)11(15)13(17-4)14(18-5)12(10)16/h6H,7H2,1-5H3

InChI key

SOECUQMRSRVZQQ-UHFFFAOYSA-N

General description

Coenzyme Q (CoQ) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. It is a ubiquinone homolog with a short isoprenoid side chain.[1]

Application

Coenzyme Q1 has been used to measure the mitochondrial respiratory chain complex 1 activity.[2][3][4][5]

Biochem/physiol Actions

Coenzyme Q1 (CoQ1) is a 1 isoprenyl group (not naturally occurring) member of a family of ubiquinones that share a quinine chemical group but differ in the number of isoprenyl chemical subunits in their tail. The CoQ compounds are lipid soluble components of cell membranes where they perform multiple functions such as electron and proton transport. The most well studied CoQ compound is CoQ10. CoQ1 is frequently used in comparison studies on the effect of isoprenyl chain length on CoQ functions or distribution and to identify quinone reductases.

Other Notes

Analog of coenzyme Q10 (not naturally occurring)

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Kathrin Fenn et al.
Microbiome, 5(1), 161-161 (2017-12-22)
The human gut microbiome has been linked to numerous components of health and disease. However, approximately 25% of the bacterial species in the gut remain uncultured, which limits our ability to properly understand, and exploit, the human microbiome. Previously, we
Chang Sun et al.
Nature, 557(7703), 123-126 (2018-04-27)
Alternative complex III (ACIII) is a key component of the respiratory and/or photosynthetic electron transport chains of many bacteria1-3. Like complex III (also known as the bc1 complex), ACIII catalyses the oxidation of membrane-bound quinol and the reduction of cytochrome
C Edlund et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 70(6), 422-428 (1992-06-01)
The lipid compositions of various regions of the human brain were investigated during aging and in Alzheimer's disease. The phospholipid amounts and compositions remained unchanged during aging. There were, however, considerable differences both in phospholipid composition and amount when the
Nandita Shangari et al.
Methods in enzymology, 400, 342-359 (2006-01-10)
Phase II conjugation of phenolic compounds constitutes an important mechanism through which exogenous or endogenous toxins are detoxified and excreted. Species differences in the rates of glucuronidation or sulfation can lead to significant variation in the metabolism of this class
Kenichi Okamura et al.
Journal of pharmacological sciences, 141(1), 56-63 (2019-10-16)
Concomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. The integral function of mitochondrial respiration is critically important for

Questions

1–2 of 2 Questions  
  1. What is the concentration?

    1 answer
    1. Product C7956 may present as a viscous liquid. Although a specific density has not been assigned due to the product being packaged by weight, there is a predicted density for this compound which is approximately 1.10 ±0.1 g/mL. This implies that for every 10 mg of material, the volume is expected to be around 9.1 µL. The molecular weight of this product is 250.29 g/mol, resulting in a concentration of roughly 4.39 M.

      Helpful?

  2. Hi, I use CoQ1 for COX I enzyme activity assay. Can this Coenzyme Q1(C7956) dissolve in water?

    1 answer
    1. We have only tested this item's solubility in acetone at 50 mg/ml. Upon further research, this item looks to be poorly soluble in water.

      Helpful?

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