Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

A5879

Sigma-Aldrich

2-(2-Aminoethyl)isothiourea dihydrobromide

Synonym(s):

2-(2-Aminoethyl)-2-thiopseudourea dihydrobromide, AET, S-(2-Aminoethyl)isothiouronium bromide hydrobromide

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Linear Formula:
NH2CH2CH2SC(=NH)NH2 · 2HBr
CAS Number:
56-10-0
Molecular Weight:
281.01
Beilstein:
3911163
EC Number:
200-257-0
MDL number:
MFCD00037011
UNSPSC Code:
12352200
PubChem Substance ID:
24278229
NACRES:
NA.77
Pricing and availability is not currently available.

Assay

≥98% (TLC)

Quality Level

100

form

powder

mp

190-196 °C (lit.)

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to yellow

SMILES string

Br[H].Br[H].NCCSC(N)=N

InChI

1S/C3H9N3S.2BrH/c4-1-2-7-3(5)6;;/h1-2,4H2,(H3,5,6);2*1H

InChI key

XDVMCVGTDUKDHL-UHFFFAOYSA-N

Gene Information

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

Looking for similar products? Visit Product Comparison Guide

Application

2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).

Biochem/physiol Actions

Inhibits constitutive and inducible NOS.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000414166
0000414166
0000371413
0000338315
0000338316

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

HAT Media Supplement (50×) Hybri-Max™ γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

Sigma-Aldrich

H0262

HAT Media Supplement (50×) Hybri-Max™

Hydroxyurea 98%, powder

Sigma-Aldrich

H8627

Hydroxyurea

O A Strand et al.
Scandinavian journal of clinical and laboratory investigation, 57(2), 105-109 (1997-04-01)
The effect of inhibiting nitric oxide (NO) synthesis during sepsis was studied in a caecal perforation model on Wistar rats. This model induces severe abdominal sepsis with a 48-h mortality > 90% in untreated animals. The survival time in hours
J L Fuentes et al.
Mutation research, 422(2), 339-345 (1998-12-05)
The effect of sodium diethyldithiocarbamate (DDC) and S-2-aminoethyl-isothiouronicadenosin-5-triphosphate (adeturon) in the induction of Escherichia coli SOS response promoted by gamma-irradiation was studied by measuring the induction of sulA gene and the induction of lambda prophage. Furthermore, as a way of
Y Gundersen et al.
The European journal of surgery = Acta chirurgica, 165(12), 1167-1174 (2000-01-15)
To examine the effects of the inducible nitric oxide synthase inhibitor aminoethyl-isothiourea (AE-ITU) on haemodynamic measurements, and correlate these with hepatic morphology and function in a porcine model of endotoxaemia. Experimental study. 15 juvenile pigs. Flow probes were placed around
T Saetre et al.
Shock (Augusta, Ga.), 9(2), 109-115 (1998-03-06)
The role of nitric oxide (NO) in hepatic oxygen transport is unclear. We investigated the effects of aminoethyl-isothiourea (AE-ITU), a selective inhibitor of iNOS activity, on liver blood flow and oxygen consumption (VO2H) in the pig. Endotoxin (lipopolysaccharide, LPS) was
A Southey et al.
International journal of immunopharmacology, 19(11-12), 669-676 (1998-07-21)
Overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) may contribute to the pathophysiology of ulcerative colitis. A 2,4,6-trinitrobenzenesulfonic acid sodium salt (TNBS) colitis model was established to examine the effect of selective iNOS inhibition, by S-(2-aminoethyl) isothiouronium
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service