Cell Marque labeled products are not tested for use in Immunofluorescence on frozen tissue. These products are only tested for Immunohistochemistry on Formalin Fixed Paraffin Embedded (FFPE) tissues.
Pricing and availability is not currently available.
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biological source
mouse
Quality Level
100
500
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
JC70, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (131M-94)
vial of 0.5 mL concentrate (131M-95)
bottle of 1.0 mL predilute (131M-97)
vial of 1.0 mL concentrate (131M-96)
bottle of 7.0 mL predilute (131M-98)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG1κ
control
tonsil
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic, membranous
Gene Information
human ... PECAM1(5175)
General description
CD31, or platelet/endothelial cell adhesion molecule-1 (PECAM-1), is a vascular cell adhesionand signaling molecule that plays a role in maintaining the vascular permeability barrierat endothelial cell junctions. Immunohistochemical detection of CD31 shows cytoplasmicand membranous expression in non-neoplastic and neoplastic vascular endothelial cells,including neoplasms of vascular origin such as hemangiomas and angiosarcomas.
Linkage
CD31 Positive Control Slides, Product No. 131S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Other Notes
For Technical Service please contact: 800-665-7284 or email: [email protected]
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Malak Abedalthagafi et al.
Annals of diagnostic pathology, 14(1), 15-22 (2010-02-04)
Cutaneous angiosarcoma (AS) is a rare malignant neoplasm of dermis composed of infiltrating cells of endothelial phenotype with overall poor prognosis. Although autocrine stimulation by vascular endothelial growth factor secretion may play a role in the pathogenesis of angiosarcoma, its
R L Attanoos et al.
Thorax, 55(10), 860-863 (2000-09-19)
Three cases of diffuse malignant vascular tumours of the pleura are described which mimicked malignant mesothelioma clinically and pathologically (so called "pseudomesothelioma"). All had occupational histories of exposure to asbestos. The relationship of these tumours to mesothelioma and asbestos exposure
Xiu-Lian Xu et al.
The American Journal of dermatopathology, 32(8), 837-840 (2010-10-01)
Microvenular hemangioma (MVH) is an uncommon benign vascular neoplasm that usually occurs as a solitary asymptomatic red or purple papule, nodule, or plaque with a predilection for the upper extremities. Patients with more than 1 lesion, that is, multiple MVHs
CD31: An Immunospecific Marker for Endothelial Differentiation in Human Neoplasms
DeYoung BR, et al.
Appl. Immunohistochem., 1, 97-100 (1993)
F Alexander-Sefre et al.
Journal of clinical pathology, 56(10), 786-788 (2003-09-30)
Lymphovascular space invasion (LVSI) is an important step in the complex process of tumour metastasis. Various methods have been used in the past to improve the histological detection of LVSI. To develop a sensitive immunohistochemical method for the detection of
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Is it also suitable to use for Immunofluorescent staining of frozen tissues (Not parafin-embeded or formalin-fixed)?
1 answer-
Helpful?
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Is there information regarding the cross reactivity with rats and can this be used on rat samples?
1 answer-
Unfortunately, we do not have any data on how this would work on rat tissue, as we only run our antibodies on Human tissue for IHC.
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