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922749

Sigma-Aldrich

Poly(2-methacryloyloxyethyl phosphorylcholine)

Mn 9000

Synonym(s):

PMPC

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About This Item

Linear Formula:
(C11H22NO6P)n
NACRES:
NA.23

form

powder or crystals

Quality Level

100

mol wt

Mn 9000

color

white to beige

SMILES string

O=C(OCCOP(OCC[N+](C)(C)C)([O-])=O)C(C)(C)CC

Related Categories

Application

Poly (2-Methacryloyloxyethyl phosphorylcholine) (PMPC) is a methacrylate based polymer with a zwitterionic phosphorylcholine moiety on the side chain. The phosphorylcholine moiety is very similar to the head group of phospholipids in cell membranes. Due to this unique structure, PMPC showed excellent resistance to nonspecific protein adsorption, cell adhesion, and blood coagulation, as well as cell membrane penetration and underwater lubrication. PMPC has been widely exploited in a diverse range of applications, such as antifouling materials for water treatment, bioengineering, and nanomedicine.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW0309
MKCT4723
MKCT0871
MKCS2425
MKCP9974

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Critical update on 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer science
T Goda, et al.
Journal of Applied Polymer Science, 132, 41766-41766 (2015)
Andrew Lewis et al.
Bioconjugate chemistry, 19(11), 2144-2155 (2008-11-01)
The water-soluble, biocompatible polymer poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) was evaluated for protein conjugation. PMPC is a zwitterionic polymer that is able to form a more compact conformation in aqueous solution than poly(ethylene glycol) (PEG). While a terminally functionalized N-hydroxysuccinimide derivative of

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