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SML3346

Sigma-Aldrich

3-PEHPC

≥95% (HPLC)

Synonym(s):

α-Hydroxy-α-phosphono-3-pyridinepropanoic acid;, 2-Hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid, NE10790

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About This Item

Empirical Formula (Hill Notation):
C8H10NO6P
CAS Number:
152831-36-2
Molecular Weight:
247.14
MDL number:
MFCD20233001
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

[P](=O)(O)(O)C(O)(Cc1cnccc1)C(=O)O

InChI key

FJVYPXVLXQXDHM-UHFFFAOYSA-N

Biochem/physiol Actions

3-PEHPC (NE 10790), a phosphonocarboxylate analogue of the bisphosphonate risedronate, is a potent and selective inhibitor of geranylgeranyl transferase II (GGTase II).
Potent and selective inhibitor of geranylgeranyl transferase II (GGTase II)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000229394
0000229393
0000229394

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Caihong Wang et al.
Autophagy, 15(3), 527-542 (2018-10-20)
50% of Caucasians carry a Thr300Ala variant (T300A) in the protein encoded by the macroautophagy/autophagy gene ATG16L1. Here, we show that the T300A variant confers protection against urinary tract infections (UTIs), the most common infectious disease in women. Using knockin
Beth Binnington et al.
Glycobiology, 26(2), 166-180 (2015-09-26)
Statins, which specifically inhibit HMG Co-A reductase, the rate-limiting step of cholesterol biosynthesis, are widely prescribed to reduce serum cholesterol and cardiac risk, but many other effects are seen. We now show an effect of these drugs to induce profound

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