SML0493

T16Ainh-A01

≥95% (HPLC)

• Synonym(s): 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide
• Empirical Formula (Hill Notation): C₁₉H₂₀N₄O₃S₂
• CAS Number: 552309-42-9
• Molecular Weight: 416.52
• MDL number: MFCD03278952
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825443
• NACRES: NA.77

Properties

• Assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: room temp
• SMILES string: CCc1c(C)nc(SCC(=O)Nc2nc(cs2)-c3ccc(OC)cc3)nc1O
• InChI: 1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)
• InChI key: QSIYTNYMBWYHAA-UHFFFAOYSA-N

Description

Application

T16Ainh-A01 has been used as an inhibitor of transmembrane protein 16A (TMEM16A).

Biochem/physiol Actions

T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 does not alter cytoplasmic calcium and has little effect on CFTR Cl- conductance.

T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor...

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable