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S5951

Sigma-Aldrich

SW02

Synonym(s):

4-(4-Bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-1(2H)-pyrimidinebutanoic acid methyl ester

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About This Item

Empirical Formula (Hill Notation):
C19H23BrN2O5
CAS Number:
1010820-68-4
Molecular Weight:
439.30
MDL number:
MFCD17215960
UNSPSC Code:
12352200
PubChem Substance ID:
329824558
NACRES:
NA.77
Pricing and availability is not currently available.

Assay

≥98% (HPLC)

Quality Level

100

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

CCOC(=O)C1=C(C)N(CCCC(=O)OC)C(=O)NC1c2ccc(Br)cc2

InChI

1S/C19H23BrN2O5/c1-4-27-18(24)16-12(2)22(11-5-6-15(23)26-3)19(25)21-17(16)13-7-9-14(20)10-8-13/h7-10,17H,4-6,11H2,1-3H3,(H,21,25)

InChI key

YFZRMRYVWWUQME-UHFFFAOYSA-N

Application

SW02 may be used in Hsp70-mediated cell signaling studies.

Biochem/physiol Actions

SW02 is a specific activator/agonist of Hsp70.
SW02 is a specific activator/agonist of Hsp70. Hsp70 is of particular interest in diseases caused by protein misfolding, such as tau and Aβ in Alzheimer′s. SW02 increases Hsp70 ATPase activity, resulting in increased tau protein but not other disease-related proteins in cells. Hsp70 prevents aggregation of Aβ peptide, as shown by treatment with SW02.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
050M4618V
0000113086
0000113087
0000061005
0000035263

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Rati Lama et al.
The Journal of steroid biochemistry and molecular biology, 168, 91-101 (2017-02-19)
Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) is identified as a novel inhibitor of estrogen stimulated breast cell growth, and it suppresses estrogen receptor-α transcriptional activity. HEXIM1 protein level has been found to be downregulated by estrogens. Recently, HEXIM1 has been

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