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P5248

Sigma-Aldrich

Etidronate disodium hydrate

≥97% (NMR), solid

Synonym(s):

Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate

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About This Item

Empirical Formula (Hill Notation):
C2H6Na2O7P2 · xH2O
CAS Number:
Molecular Weight:
249.99 (anhydrous basis)
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥97% (NMR)

form

solid

color

white

mp

>300 °C

solubility

H2O: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChI key

GWBBVOVXJZATQQ-UHFFFAOYSA-L

Application

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

Biochem/physiol Actions

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.
Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Etidronate protects chronic ocular hypertension induced retinal oxidative stress and promotes retinal ganglion cells growth through IGF-1 signaling pathway
Su J and Huang M
European Journal of Pharmacology, 841, 75-81 (2018)
Ping Yin et al.
Bioresource technology, 128, 36-43 (2012-12-01)
Novel biomass-based adsorbents organophosphonic acid functionalized spent buckwheat hulls (OPA-BH) with 60 mesh were successfully employed to adsorb Au(III) ions from simulated wastewater. The adsorption kinetics and isotherms both in unary ion system and in ternary ions system were investigated
Meghan E Faillace et al.
Calcified tissue international, 92(1), 50-58 (2012-11-13)
Mineralizing osteoblasts are regularly used to study osteogenesis and model in vivo bone formation. Thus, it is important to verify that the mineral and matrix being formed in situ are comparable to those found in vivo. However, it has been
Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes
Griffin S, et al.
Biology of Reproduction (2018)
Synthesis of bisphosphonate derivatives of ATP by T4 RNA ligase
Sillero M A G, et al.
Febs Letters, 580(24), 5723-5727 (2006)

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