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M3324

Sigma-Aldrich

M100907

≥98% (HPLC)

Synonym(s):

(R)-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol, MDL100907, Volinanserin

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About This Item

Empirical Formula (Hill Notation):
C22H28FNO3
CAS Number:
139290-65-6
Molecular Weight:
373.46
MDL number:
MFCD00909060
UNSPSC Code:
12352200
PubChem Substance ID:
329817971
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

off-white to light brown

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC

InChI

1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1

InChI key

HXTGXYRHXAGCFP-OAQYLSRUSA-N

Gene Information

human ... HTR2A(3356)

General description

M100907 blocks the serotonin 2A (5-HT2A) receptors and imposes antidepressant-like effects. It may be used for treating dopaminergic anomalies.

Biochem/physiol Actions

M100907 is a selective 5-HT2A Antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kerry A Waters et al.
Behavioural brain research, 228(1), 211-218 (2011-12-23)
The 5-hydroxytryptamine7 (5-HT7) receptor is a G-protein coupled receptor for serotonin that has been implicated in the pathophysiology of psychiatric and neurological disorders including anxiety, depression and schizophrenia. A number of studies have attempted to evaluate the potential role of
Ashley Furr et al.
The international journal of neuropsychopharmacology, 15(9), 1295-1305 (2011-10-20)
Chronic stress is a risk factor for depression, and chronic stress can induce cognitive impairments associated with prefrontal cortical dysfunction, which are also major components of depression. We have previously shown that 5 wk chronic intermittent cold (CIC) stress induced
Mona E Hervig et al.
Psychology & neuroscience, 13(3), 438-458 (2021-02-23)
Adapting behavior to a dynamic environment requires both steadiness when the environment is stable and behavioral flexibility in response to changes. Much evidence suggests that cognitive flexibility, which can be operationalized in reversal learning tasks, is mediated by cortico-striatal circuitries
Peter S Talbot et al.
NeuroImage, 59(1), 271-285 (2011-07-26)
Scanning properties and analytic methodology of the 5-HT2A receptor-selective positron emission tomography (PET) tracer 11C-MDL100907 have been partially characterised in previous reports. We present an extended characterisation in healthy human subjects. 64 11C-MDL100907 PET scans with metabolite-corrected arterial input function
Paul J Fletcher et al.
Neuropharmacology, 61(3), 468-477 (2011-03-16)
Previous work has shown that 5-HT(2C) receptor agonists and 5-HT(2A) receptor antagonists reduce impulsive action, as well as the locomotor stimulant effect of psychomotor stimulants. Since psychomotor stimulants also increase impulsive action we examined the effects of the 5-HT(2C) receptor
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